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Full-Text Articles in Medicine and Health Sciences
The Brain-Heart Connection: Establishment Of A Novel Rodent Model Of Focal Insular Ischemic Stroke To Examine The Pathophysiology Of Stroke-Induced Heart Injury, Victoria Thorburn
The Brain-Heart Connection: Establishment Of A Novel Rodent Model Of Focal Insular Ischemic Stroke To Examine The Pathophysiology Of Stroke-Induced Heart Injury, Victoria Thorburn
Electronic Thesis and Dissertation Repository
The neurological influence of ischemic stroke in the generation of stroke-induced heart injury (SIHI) has been acknowledged for several years. However, pathophysiological mechanisms remain uncertain. Clinically, it is hypothesized that stroke involving the insular cortex (IC) initiates SIHI, since the IC controls autonomic regulation of cardiovascular function. Yet, given the high prevalence of shared risk factors between ischemic stroke and cardiovascular disorders, mechanistic conclusions from clinical studies are largely speculative. We therefore sought to establish a novel rodent model of focal insular ischemic stroke, used to evaluate chronic outcomes of SIHI. Focal ischemic stroke was induced into the right or …
Behavioural Inflexibility And White Matter Inflammation In An Aged Happ Rat With Subcortical Stroke, Aaron M. Regis
Behavioural Inflexibility And White Matter Inflammation In An Aged Happ Rat With Subcortical Stroke, Aaron M. Regis
Electronic Thesis and Dissertation Repository
The interactions between Alzheimer’s disease (AD) and ischemic stroke pathology are of key interest in the development of post-stroke cognitive decline. While clinical and experimental studies have suggested an interaction, the mechanisms whereby these conditions interact to worsen cognition haven’t been fully revealed. This study aimed to combine rodent models of AD and stroke in an aged rat and assess the behavioural and histological outcomes. An injection of endothelin-1 (ET-1), a potent vasoconstrictor into the basal ganglia of a rat with human amyloid precursor protein (hAPP) overexpression (F344Tg) was followed up 3 months later to assess behavioural flexibility, memory and …