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Full-Text Articles in Medicine and Health Sciences
Analysis Of Subchondral Bone And Microvessels Using A Novel Vascular Perfusion Contrast Agent And Optimized Dual-Energy Computed Tomography, Justin J. Tse
Electronic Thesis and Dissertation Repository
Osteoarthritis (OA), is a chronic debilitating disease that affects millions of individuals and is characterized by the degeneration of joint subchondral bone and cartilage. These tissue degenerations manifest as joint pain, limited range of joint motion, and overall diminished quality of life. Currently, the exact mechanism(s) and cause(s) by which OA initiates and progresses remain unknown. The multi-factorial complex nature of OA (i.e. age, diabetes, obesity, and prior injuries have all been shown to play a role in OA) contributes to the current lack of a cure or effective long-term treatment for OA.
One re-emerging and interesting hypothesis …
Peroxisome Proliferator Activated Receptor Delta In Osteoarthritis, Anusha Ratneswaran
Peroxisome Proliferator Activated Receptor Delta In Osteoarthritis, Anusha Ratneswaran
Electronic Thesis and Dissertation Repository
Osteoarthritis (OA) affects 1 in 10 Canadians and is a leading cause of mobility disability worldwide. This condition is characterized by cartilage degeneration, subchondral bone damage and inflammation of the synovium, resulting in pain and joint failure. No treatments exist to stop the progression of this disease, and its underlying molecular mechanisms remain largely unknown. We previously identified the peroxisome proliferator activated receptor (PPAR) nuclear receptor pathway as altered in OA cartilage. In-vitro studies identified PPARd as a promoter of catabolic activity in chondrocytes, providing the foundation for my overarching hypothesis that PPARd inhibition is protective in OA.
I commenced …