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Research Brief: "Disparities In The Consequences Of Sarcopenia: Implications For African American Veterans", Institute For Veterans And Military Families At Syracuse University
Research Brief: "Disparities In The Consequences Of Sarcopenia: Implications For African American Veterans", Institute For Veterans And Military Families At Syracuse University
Institute for Veterans and Military Families
This brief shows why more research should be done on African American veterans who have sarcopenia. In policy and practice, African American veterans should tell their healthcare providers about their geriatric medical needs, and health professionals should inform their veteran patients about how to avoid muscle wasting that can lead to sarcopenia; the VA should provide criteria for diagnosing sarcopenia among aging veterans. Suggestions for future research include analysis of the relation between myosteatosis and diabetes, as well as focusing on understanding the effects of sarcopenia on African American veterans.
Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, Kyle Remington Struthers
Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, Kyle Remington Struthers
Master's Theses
Functional vasodilation in arterioles is impaired with chronic ischemia. We sought to examine the impact of chronic ischemia and age on skeletal muscle resistance artery function. To examine the impact of chronic ischemia, the femoral artery was resected from young (2-3mo) and adult (6-7mo) mice and the profunda femoris artery diameter was measured at rest and following gracilis muscle contraction 14 days later using intravital microscopy. Functional vasodilation was significantly impaired in ischemic mice (14.4±4.6% vs. 137.8±14.3%, p<0.0001 n=8) and non-ischemic adult mice (103.0±9.4% vs. 137.8±14.3%, p=0.05 n=10). In order to analyze the cellular mechanisms of the impairment, a protocol was developed to apply pharmacological agents to the experimental preparation while maintaining tissue homeostasis. Endothelial and smooth muscle dependent vasodilation were impaired with ischemia, 39.6 ± 13.6% vs. 80.5 ± 11.4% and 43.0 ± 11.7% vs. 85.1 ± 10.5%, respectively. From this data, it can be supported that smooth muscle dysfunction is the reason for the observed impairment in arterial vasodilation.