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Full-Text Articles in Medicine and Health Sciences
The Threat Of Antibiotic Resistance In Changing Climate, Aliyar Cyrus Fouladkhah, Brian Thompson, Janey Smith Camp
The Threat Of Antibiotic Resistance In Changing Climate, Aliyar Cyrus Fouladkhah, Brian Thompson, Janey Smith Camp
Agricultural and Environmental Sciences Faculty Research
As the earliest form of life, microorganisms have elaborate mechanisms for adapting to changes in environmental conditions.
Molecular Mechanisms Of Antimicrobial Resistance In Multi-Drug Resistant Enterococci, Ayesha Khan
Molecular Mechanisms Of Antimicrobial Resistance In Multi-Drug Resistant Enterococci, Ayesha Khan
Dissertations & Theses (Open Access)
Antibiotic resistance is a major global public health threat. Enterococci are recalcitrant, nosocomial pathogens that can be intrinsically resistant to valuable antibiotics, like beta-lactams, or evolve resistance to all existing antimicrobials. The LiaFSR system regulates resistance to cell membrane (CM) stressors like daptomycin (DAP), a front-line drug for multi-drug resistant infections. DAP resistance (DAP-R) in E. faecalis is mediated by CM phospholipid alterations. Emergence of DAP-R often leads to b-lactam resensitization, a phenomenon called the seesaw effect. The molecular mechanism of DAP-R and the seesaw effect are unknown. Here we show that LiaX is a surface exposed protein whose C-terminal …