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Sex Differences In Cognitive Changes In De Novo Parkinson’S Disease, Ece Bayram, Sarah J. Banks, Guogen Shan, Nikki Kaplan, Jessica Z.K. Caldwell

Environmental & Occupational Health Faculty Publications

Objective: To evaluate the sex differences in cognitive course over 4 years in Parkinson’s disease (PD) patients with and without mild cognitive impairment (MCI) compared to controls. Methods: Four-year longitudinal cognitive scores of 257 cognitively intact PD, 167 PD-MCI, and 140 controls from the Parkinson’s Progression Markers Initiative were included. Longitudinal scores of men and women, and PD with and without MCI were compared. Results: Women had better verbal memory, men had better visuospatial function. There was no interaction between sex, diagnostic group, and/or time (4-year follow-up period). Conclusions: Sex differences in cognitive course in de novo PD are similar …