Medicine and Health Sciences Commons^™

Is Incidence Of Nausea Influenced By Brintellix In Patients Over The Age Of 18 With Major Depressive Disorder?, Juris Eyler

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The Objective of this selective EBM review is to determine where or not, “Is Incidence of Nausea Influenced by Brintellix (Vortioxetine) in Patients over the Age of 18 with Major Depressive Disorder (MDD)?”

STUDY DESIGN: Review of three English language primary studies, published between 2011 and 2013

DATA SOUCES: Three double blind randomized controlled trials (RCTs). Sources were found on PubMed and Cochrane Library databases.

OUTCOMES MEASURED: To measure the incidence of nausea in patients over 18 who are diagnosed with major depressive disorder taking Brintellix compared to a placebo.

RESULTS: The randomized controlled studies results found that Brintellix …

Is Yoga An Effective Treatment For Post-Traumatic Stress Disorder (Ptsd)?, Marissa Ionna

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Is Yoga An Effective Treatment For Post-Traumatic Stress Disorder (PTSD)?”

Study Design: Systematic review of three randomized controlled trials (RCTs) published in peer reviewed journals between 2010-2014, all English language.

Data Sources: Three randomized controlled trials were found using PubMed.

Outcomes Measured: All three studies measured improvement in PTSD symptoms through yoga therapy using self-reported patient questionnaires, visual analog scales, and vital signs.

Results: Studies by Telles et al. and van der Kolk et al. found that yoga therapy significantly improved symptoms in patients with Post-Traumatic …

Is Flibanserin A Safe And Effective Treatment To Increase Sexual Desire In Premenopausal Women With Hypoactive Sexual Desire Disorder?, Rebecca Lee

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Flibanserin is a safe and effective treatment to increase sexual desire in premenopausal women with Hypoactive Sexual Desire Disorder.

STUDY DESIGN: Review of three randomized controlled trials published in 2013, 2012, and 2012; selection was based on their relevance to the clinical question and if they contained patient oriented outcomes.

DATA SOURCES: Three peer-reviewed randomized controlled trials comparing the use of Flibanserin to placebo in the treatment of Hypoactive Sexual Desire Disorder were found on PubMed.

OUTCOME(S) MEASURED: For each trial patients were divided into two …

Does Yoga Decrease Self-Report Of Antenatal Depression Among Healthy Pregnant Women Aged 18-40 Years Old In The 2nd And 3rd Trimesters?, Emily J. Moore

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not yoga decreases self-report of antenatal depression among healthy pregnant women aged 18-40 years old in the 2nd and 3rd trimesters.

Study Design: Review of three randomized controlled trials (RCTs) published in peer reviewed journals in 2013 and one RCT published in a peer reviewed journal in 2012 were used.

Data Source: Data sources included articles published in English in peer reviewed journals found using PubMed. Articles were selected based on their relevance to my clinical question.

Outcomes Measured: All four studies measured self-report of symptoms of …

Does Cognitive Remediation Therapy (Crt) Improve The Neuropsychological Function In Patients With Anorexia Nervosa?, Lindsay M. Padden

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not cognitive remediation therapy (CRT) improves the neuropsychological function in patients with anorexia nervosa.

STUDY DESIGNS: Review of two randomized controlled trials and one non-randomized case series, published in 2012, 2013 and 2014.

DATA SOURCES: The three studies used in this review were published in English and found in PubMed.

OUTCOMES MEASURED: For all studies, neuropsychological function, such as memory, attention, and cognitive flexibility, were measured using pre- and post-treatment questionnaires. One study used a computerized task-shifting paradigm to determine cognitive flexibility.

RESULTS: Brockmeyer et al. and …

Is Dance/Movement Therapy An Effective Treatment For Depression In Students?, Jillian R. Ranker

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence-based medicine (EBM) review is to determine whether or not Dance/Movement Therapy (DMT) is an effective treatment for depression in students.

STUDY DESIGN: Systematic review of three published, randomized controlled trials (RCTs) between 2005 and 2013, all English language

DATA SOURCES: Three RCTs analyzing DMT use in depression were found using PudMed

OUTCOMES MEASURED: Decrease in depressive symptoms, measured by the Beck Depression Scale, a self-rated health questionnaire, and Symptom Check List-90-Revision (SCL- 90-R)

RESULTS: DMT resulted in lessened depressive symptoms for students in all three RCTs. Jeong et al. observed a significant decrease …

Does The Use Of Oral Amphetamines Reduce Cocaine Use In Cocaine-Dependent Individuals?, Kevin M. Strate

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not the use of oral amphetamines reduces cocaine use in cocaine-dependent individuals.

Study Design: Review of three English language randomized control trials (RCTs) published in 2001, 2003 and 2004.

Data Sources: 3 randomized controlled trials published after 1999 were obtained using PubMed, OVID, and Medline.

Outcomes Measured: The efficacy of using d-amphetamine to promote cocaine use cessation in cocaine-dependent individuals, determined using immunoassay and mass spectrometric analysis to identify cocaine metabolites in the participant’s urine.

Results: Grabowski et al (2004) found a significant reduction in the use …

Does Exogenous Melatonin Improve Quality Of Sleep In Patients Experiencing Sleep Disturbances Secondary To Chronic Diseases?, Blessen B. Thomas

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Does exogenous melatonin improve quality of sleep in patients experiencing sleep disturbances secondary to chronic diseases?”

Study Design: Three Randomized, placebo-controlled studies (RCT) published in 2010, 2013 and 2008. Data Sources: All RCTs searched and located using PubMed database.

Outcomes Measured: Clinical outcome for all three articles using quality of sleep or quality of life questionnaires such as the Leeds Sleep Evaluation. All of which evaluated POEMs, and were self reported by participants.

Results: In a randomized control study (RCT) by Serfaty et al, sleep quality …