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Full-Text Articles in Medicine and Health Sciences
Hypertension In Children And Adolescents: Epidemiology And Natural History., Bonita Falkner
Hypertension In Children And Adolescents: Epidemiology And Natural History., Bonita Falkner
Department of Medicine Faculty Papers
Primary hypertension is detectable in children and adolescents and, as in adults, is associated with a positive family history of hypertension, obesity, and life-style factors. Owing to the well-established childhood obesity epidemic, the population prevalence of high blood pressure (BP) in the young is increasing. Hypertension in childhood is commonly associated with other cardiovascular risk factors as well as obesity. Although death and cardiovascular disability do not occur in hypertensive children, intermediate markers of target organ damage, such as left ventricular hypertrophy, thickening of the carotid vessel wall, retinal vascular changes, and even subtle cognitive changes, are detectable in children …
Biomarkers In Systemic Sclerosis., Susan V. Castro, Sergio A. Jimenez
Biomarkers In Systemic Sclerosis., Susan V. Castro, Sergio A. Jimenez
Scleroderma Center Faculty Papers
Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the three main pathogenetic mechanisms in systemic sclerosis have been described; however, aside from several disease-specific autoantibodies, other biomarkers have not been thoroughly validated and require further study. Thus, there is an unmet need for validated biomarkers for diagnosis, disease classification, and evaluation of organ involvement and therapeutic response in systemic sclerosis.