Open Access. Powered by Scholars. Published by Universities.®

Medicine and Health Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

Medical Specialties

2005

Tamoxifen

Articles 1 - 2 of 2

Full-Text Articles in Medicine and Health Sciences

Oncolog, Volume 50, Number 07/08, July-August 2005, Rachel Williams, Sunni Hosemann Jul 2005

Oncolog, Volume 50, Number 07/08, July-August 2005, Rachel Williams, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

  • Getting Proactive About Prevention
  • New Techniques in Tumor Ablation
  • House Call: Calling for Help: Cancer Helplines and What They Offer

Go to article

Effects Of Tamoxifen On Mitochondrial Nos Activity: Alteration In The Intramitochondrial Ca2+ Homeostasis, Sandeep S. Joshi Jan 2005

Effects Of Tamoxifen On Mitochondrial Nos Activity: Alteration In The Intramitochondrial Ca2+ Homeostasis, Sandeep S. Joshi

Theses, Dissertations and Capstones

Tamoxifen (Tam) is an anticancer drug that induces oxidative stress and apoptosis via mitochondria- and nitric oxide (NO)-dependent pathways. Here, we report that therapeutic concentrations of Tam stimulate the mitochondrial NO synthase (mtNOS) activity of isolated rat liver mitochondria by increasing the intramitochondrial ionized Ca2+ concentration ([Ca2+]m). Tam decreases transmembrane potential (∆ψ) due to increased [Ca2+]m that neutralizes the negative charges of the inner mitochondrial membrane. Thus, the present study reports a novel mechanism for the widely used anti- caner drug, Tam.

Go to article