Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Jefferson Medical College (2)
- Neurofibromatosis (2)
- Presentation (2)
- A Compact Guide to the Diagnosis and Management of Neurofibromatosis Type 1 (1)
- Cafe au lait (1)
-
- Cutaneous manifestations of internal malignancy (1)
- Dermatology (1)
- Diagnosis of neurofibromatosis (1)
- Internal malignancy (1)
- Jefferson medical college (1)
- MPNST (1)
- Malignant peripheral nerve sheath tumor (1)
- Neural tumors (1)
- Neurofibromas (1)
- Neurosurgery (1)
- Pennsylvania (1)
- Philadelphia (1)
- Poster (1)
- Posters (1)
- Ras (1)
- Sarcoma (1)
- Soft tissue sarcoma (1)
- Thomas Jefferson University (1)
- Tim Beer (1)
- Tim beer (1)
- Timothy Beer (1)
- Timothy beer (1)
- United States (1)
- File Type
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Malignant Peripheral Nerve Sheath Tumor (Mpnst): An Overview With Emphasis On Pathology, Imaging And Management Strategies., Timothy C. Beer
Malignant Peripheral Nerve Sheath Tumor (Mpnst): An Overview With Emphasis On Pathology, Imaging And Management Strategies., Timothy C. Beer
Timothy C Beer
MPNSTs are rare malignancies that are classically associated with pre-existing plexiform neurofibromas in neurofibromatosis type 1 (NF-1) patients, but also occur in association with radiation as well as sporadically in patients with no known risk factors. The typical presentation of sporadic MPNST is a new painless enlarging mass. The typical presentation of MPNST in an NF-1 patient is rapid enlargement or new onset of pain associated with a pre-existing plexiform neurofibroma. Although both MPNST and benign neurofibromas share in common the absence of neurofibromin function due to loss of both NF-1 alleles, malignant transformation to MPNST requires several additional aberrations, …
A Compact Guide To The Diagnosis And Management Of Neurofibromatosis Type 1, Timothy Beer, David Strayer, Md, Phd
A Compact Guide To The Diagnosis And Management Of Neurofibromatosis Type 1, Timothy Beer, David Strayer, Md, Phd
Timothy C Beer
Brief Introduction Neurofibromatosis type 1 (NF-1) is a multisystem neurocutaneous disorder resulting from mutations in the NF-1 gene on chromosome 17 (q11.2). Mutations in NF-1 result in deficient activity of the tumor suppresor protein neurofibromin, allowing for uncontrolled constitutive activity of the proliferative Raspathway in several neural cell types, including neurons, oligodendrocytes, astrocytes and Schawnn cells. Half of NF-1 cases are inherited in autosomal dominant fashion, while half develop sporadically. The syndrome has 100% penetrance but highly variable expressivity. The prevalence of this syndrome is 1/3,000, making it common enough to warrant YOU, the physician, taking a moment to learn …
Cutaneous Manifestations Of Internal Malignancy: A Case-Based Lesson, Timothy Beer
Cutaneous Manifestations Of Internal Malignancy: A Case-Based Lesson, Timothy Beer
Timothy C Beer
A case-based lesson covering 10 cutaneous manifestations associated with internal malignancies.