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Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Increased Risk For Vitamin D Deficiency In Obese Children With Both Celiac Disease And Type 1 Diabetes, Nithya Setty-Shah, Louise S. Maranda, Benjamin U. Nwosu
Increased Risk For Vitamin D Deficiency In Obese Children With Both Celiac Disease And Type 1 Diabetes, Nithya Setty-Shah, Louise S. Maranda, Benjamin U. Nwosu
Benjamin U. Nwosu
Background. It is unknown whether the coexistence of type 1 diabetes (T1D) and celiac disease (CD) increases the risk for vitamin D deficiency.
Aims. To determine the vitamin D status and the risk for vitamin D deficiency in prepubertal children with both T1D and CD compared to controls, TID, and CD.
Subjects and Methods. Characteristics of 62 prepubertal children of age 2–13 y with either CD + T1D (� = 22, 9.9 ± 3.1 y), CD only (� = 18, 8.9 ± 3.3 y), or T1D only (� = 22, 10.1 ± 2.8 y) were compared to 49 controls of …
The Vitamin D Status In Inflammatory Bowel Disease, Lauren Veit, Louise Maranda, Jay G. Fong, Benjamin U. Nwosu
The Vitamin D Status In Inflammatory Bowel Disease, Lauren Veit, Louise Maranda, Jay G. Fong, Benjamin U. Nwosu
Benjamin U. Nwosu
CONTEXT: There is no consensus on the vitamin D status of children and adolescents with inflammatory bowel disease (IBD).
AIM: To determine the vitamin D status of patients with IBD by comparing their serum 25(OH)D concentration to that of healthy controls.
HYPOTHESIS: Serum 25(OH)D concentration will be lower in patients with IBD compared to controls.
SUBJECTS AND METHODS: A case-controlled retrospective study of subjects with IBD (n = 58) of 2-20 years (male n = 31, age 16.38±2.21 years; female n = 27, age16.56±2.08 years) and healthy controls (n = 116; male n = 49, age 13.90±4.59 years; female n …
Data From: The Effects Of Vitamin D Supplementation On Hepatic Dysfunction, Vitamin D Status, And Glycemic Control In Children And Adolescents With Vitamin D Deficiency And Either Type 1 Or Type 2 Diabetes Mellitus, Benjamin U. Nwosu, Louise S. Maranda
Data From: The Effects Of Vitamin D Supplementation On Hepatic Dysfunction, Vitamin D Status, And Glycemic Control In Children And Adolescents With Vitamin D Deficiency And Either Type 1 Or Type 2 Diabetes Mellitus, Benjamin U. Nwosu, Louise S. Maranda
Benjamin U. Nwosu
Background: The effects of vitamin D supplementation on mild hepatic dysfunction and glycemic control are unclear in children and adolescents with either type 1 (T1D) or type 2 diabetes (T2D). Hypothesis: Vitamin D supplementation will improve hepatic dysfunction and glycemic control. Aim: To determine the effect of vitamin D supplementation on alanine transaminase (ALT), hemoglobin A1c (HbA1c), and serum 25-hydroxyvitamin D [25(OH)D] concentration. Subjects and Methods: A retrospective study of 131 subjects with either T1D (n=88: 46 females, 42 males), or T2D ( n=43: 26 females, 17 males) of ages 3-18 years between 2007-2013. All subjects had (1) a diagnosis …
Data From: The Vitamin D Status In Inflammatory Bowel Disease, Lauren Veit, Louise S. Maranda, Jay G. Fong, Benjamin U. Nwosu
Data From: The Vitamin D Status In Inflammatory Bowel Disease, Lauren Veit, Louise S. Maranda, Jay G. Fong, Benjamin U. Nwosu
Benjamin U. Nwosu
Manuscript abstract: Context: There is no consensus on the vitamin D status of children and adolescents with inflammatory bowel disease (IBD). Aim: To determine the vitamin D status of patients with IBD by comparing their serum 25(OH)D concentration to that of healthy controls. Hypothesis: Serum 25(OH)D concentration will be lower in patients with IBD compared to controls. Subjects and Methods: A case-controlled retrospective study of subjects with IBD (n=58) of 2-20 years (male n=31, age 16.38 ± 2.21 years; female n=27, age16.56 ± 2.08 years) and healthy controls (n=116; male n=49, age 13.90 ± 4.59 years; female n=67, age 15.04 …
The Effects Of Vitamin D Supplementation On Hepatic Dysfunction, Vitamin D Status, And Glycemic Control In Children And Adolescents With Vitamin D Deficiency And Either Type 1 Or Type 2 Diabetes Mellitus, Benjamin U. Nwosu, Louise Maranda
The Effects Of Vitamin D Supplementation On Hepatic Dysfunction, Vitamin D Status, And Glycemic Control In Children And Adolescents With Vitamin D Deficiency And Either Type 1 Or Type 2 Diabetes Mellitus, Benjamin U. Nwosu, Louise Maranda
Benjamin U. Nwosu
BACKGROUND: The effects of vitamin D supplementation on mild hepatic dysfunction and glycemic control are unclear in children and adolescents with either type 1 (T1D) or type 2 diabetes (T2D).
HYPOTHESIS: Vitamin D supplementation will improve hepatic dysfunction and glycemic control.
AIM: To determine the effect of vitamin D supplementation on alanine transaminase (ALT), hemoglobin A1c (HbA1c), and serum 25-hydroxyvitamin D [25(OH)D] concentration.
SUBJECTS AND METHODS: A retrospective study of 131 subjects with either T1D (n = 88∶46 females, 42 males), or T2D (n = 43∶26 females, 17 males) of ages 3-18 years between 2007-2013. All subjects had (1) a …
The Relationship Between Subnormal Peak-Stimulated Growth Hormone Levels And Auxological Characteristics In Obese Children, Jefferson Barrett, Louise S. Maranda, Benjamin U. Nwosu
The Relationship Between Subnormal Peak-Stimulated Growth Hormone Levels And Auxological Characteristics In Obese Children, Jefferson Barrett, Louise S. Maranda, Benjamin U. Nwosu
Benjamin U. Nwosu
Context: The hypothesis that obese children are overdiagnosed with growth hormone deficiency (GHD) has not been adequately investigated in the context of adiposity-related differences in auxology.
Aim: To investigate the differences in auxological parameters between short, prepubertal, obese children, and normal-weight peers who underwent growth hormone stimulation testing (GHST).
Hypothesis: Over-weight/obese children with GHD [peak growth hormone (GH) < 10 μg/L] will have higher values for growth velocity (GV) standard deviation score (SDS), bone age minus chronological age (BA − CA), and child height SDS minus mid-parental height (MPTH) SDS when compared to normal-weight GHD peers.
Subjects and Methods: A retrospective review of anthropometric and provocative GHST data of 67 prepubertal, GH-naïve children of age 10.21 ± 2.56 years (male n = 45, age 10.8 ± 2.60 years; female n = 22, age 8.94 ± 2.10). Inclusion …
The Relationship Between Subnormal Peak-Stimulated Growth Hormone Levels And Auxological Characteristics In Obese Children, Jefferson Barrett, Louise S. Maranda, Benjamin U. Nwosu
The Relationship Between Subnormal Peak-Stimulated Growth Hormone Levels And Auxological Characteristics In Obese Children, Jefferson Barrett, Louise S. Maranda, Benjamin U. Nwosu
Benjamin U. Nwosu
Context: The hypothesis that obese children are overdiagnosed with growth hormone deficiency (GHD) has not been adequately investigated in the context of adiposity-related differences in auxology. Aim: To investigate the differences in auxological parameters between short, prepubertal, obese children, and normal-weight peers who underwent growth hormone stimulation testing (GHST). Hypothesis: Over-weight/obese children with GHD [peak growth hormone (GH) < 10 μg/L] will have higher values for growth velocity (GV) standard deviation score (SDS), bone age minus chronological age (BA − CA), and child height SDS minus mid-parental height (MPTH) SDS when compared to normal-weight GHD peers. Subjects and Methods: A retrospective review of anthropometric and provocative GHST data of 67 prepubertal, GH-naïve children of age 10.21 ± 2.56 years (male n = 45, age 10.8 ± 2.60 years; female n = 22, age 8.94 ± 2.10). Inclusion criteria: GHST using arginine and clonidine. Exclusion criteria: hypopituitarism, abnormal pituitary magnetic resonance imaging scan, syndromic obesity, or syndromic short stature. Data were expressed as mean ± SD. Results: The over-weight/obese children with peak GH of <10 μg/L had significantly lower value for natural log (ln) peak GH (1.45 ± 0.09 vs. 1.83 ± 0.35, p = 0.022), but similar values for GV SDS, insulin-like growth factor-I, insulin-like growth factor binding protein-3, bone age, BA − CA, MPTH, and child height SDS minus MPTH SDS compared to normal-weight peers with GHD. After adjusting for covariates, the over-weight/obese children (BMI ≥ 85th percentile) were >7 times more likely than normal-weight subjects (BMI < 85th percentile) to have a peak GH of <10 μg/L, and 23 times more likely to have a peak GH of <7 μg/L (OR = 23.3, p = 0.021). There was a significant inverse …
The Vitamin D Status Of Prison Inmates, Benjamin U. Nwosu, Louise Maranda, Rosalie Berry, Barbara Colocino, Carlos D. Flores, Kerry Folkman, Thomas Groblewski, Patricia Ruze
The Vitamin D Status Of Prison Inmates, Benjamin U. Nwosu, Louise Maranda, Rosalie Berry, Barbara Colocino, Carlos D. Flores, Kerry Folkman, Thomas Groblewski, Patricia Ruze
Benjamin U. Nwosu
INTRODUCTION: There is no comprehensive, systematic analysis of the vitamin D status of prisoners in the scientific literature.
OBJECTIVE: To investigate the vitamin D status and its determinants in US prison inmates.
HYPOTHESIS: Given the uniformity of dietary intake amongst inmates, vitamin D status will be determined by non-dietary factors such as skin pigmentation, security level-, and the duration of incarceration.
SUBJECTS AND METHODS: A retrospective study of 526 inmates (males, n = 502, age 48.6±12.5 years; females, n = 24, age 44.1±12.2) in Massachusetts prisons. Vitamin D sufficiency, insufficiency, and deficiency were respectively defined as a 25(OH)D concentration 75 …