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Role Of Sirt1 In Vascular Complications Of Diabetes, Rokhsana Mortuza
Role Of Sirt1 In Vascular Complications Of Diabetes, Rokhsana Mortuza
Electronic Thesis and Dissertation Repository
Chronic diabetic complications are significant causes of morbidity. In diabetes, as the cellular changes are similar to aging, we investigated the role of sirtuins (SIRTs) in chronic diabetic complications.
We examined glucose and aging-induced changes in the endothelial cells (ECs), the primary targets of chronic diabetic complications. ECs in high glucose showed evidences of early senescence, being more pronounced in microvascular ECs in association with decreased SIRT1 and FOXO1-dependent reduction in antioxidant gene expressions. A regulatory relationship of deacetylator SIRT1 and histone acetylator p300 was identified. Renal and retinal tissues of diabetic animals showed similar results.
Having established such changes, …