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Development Of Status Epilepticus, Sustained Calcium Elevations And Neuronal Injury In A Rat Survival Model Of Lethal Paraoxon Intoxication, Laxmikant Sudhir Deshpande, Dawn S. Carter, Kristin Phillips, Robert E. Blair, Robert J. Delorenzo

Neurology Publications

Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations. Exposure to POX produces high mortality. OP poisoning is often associated with chronic neurological disorders. In this study, we optimize a rat survival model of lethal POX exposures in order to mimic both acute and long-term effects of POX intoxication. Male Sprague–Dawley rats injected with POX (4 mg/kg, ice-cold PBS, s.c.) produced a rapid cholinergic crisis that evolved into status epilepticus (SE) and death within 6–8 min. The EEG profile for POX induced SE was characterized and showed clinical and …