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Full-Text Articles in Medicine and Health Sciences
Primary Liver Cancers, Part 2: Progression Pathways And Carcinogenesis, Kun Jiang, Barbara A. Centeno
Primary Liver Cancers, Part 2: Progression Pathways And Carcinogenesis, Kun Jiang, Barbara A. Centeno
Pathology and Cell Biology Faculty Publications
Hepatocellular carcinoma (HCC) and primary intrahepatic cholangiocarcinoma (ICC) have been increasing in incidence worldwide and are leading causes of cancer death. Studies of the molecular alterations leading to these carcinomas provide insights into the key mechanisms involved. A literature review was conducted to identify articles with information relevant to current understanding of the etiologies and molecular pathogenesis of HCC and ICC. Chronic inflammatory diseases are the key etiological risk factors for both HCC and ICC, although other diseases play a role, and for many ICCs, an underlying risk factor is not identified. Mutations in catenin beta 1 (CTNBB1) …
Recurrent Aneurysmal Bone Cyst Of The Distal Fibula Treated With Denosumab And Curettage, Philip B. Fontenot, Jose Jesurajan, Marilyn Bui, Damon Reed, Odion Binitie
Recurrent Aneurysmal Bone Cyst Of The Distal Fibula Treated With Denosumab And Curettage, Philip B. Fontenot, Jose Jesurajan, Marilyn Bui, Damon Reed, Odion Binitie
Pathology and Cell Biology Faculty Publications
We report the case of a 13-year-old girl with multiple recurrences of an aneurysmal bone cyst of the distal fibula successfully treated with denosumab and curettage. Aneurysmal bone cysts are locally aggressive lesions with high rates of recurrence. The novel use of denosumab with curettage in a long bone showed a favorable outcome with no adverse events or signs of recurrence three years after treatment.
Primary Liver Cancers—Part 1: Histopathology, Differential Diagnoses, And Risk Stratification, Kun Jiang, Sameer Al-Diffalha, Barbara A. Centeno
Primary Liver Cancers—Part 1: Histopathology, Differential Diagnoses, And Risk Stratification, Kun Jiang, Sameer Al-Diffalha, Barbara A. Centeno
Pathology and Cell Biology Faculty Publications
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the 2 most common primary malignant liver tumors, with hepatocellular and bile ductular differentiation, respectively. This article reviews the key histopathological findings of these 2 primary liver cancers and includes a review of the role of ancillary testing for differential diagnosis, risk stratification according to the American Joint Committee on Cancer (AJCC) staging recommendation, and a review of precancerous lesions. A literature review was conducted to identify articles with information relevant to precancerous precursors, current histopathological classification, ancillary testing, and risk stratification of primary malignant liver tumors. The histomorphology of normal liver, preinvasive …