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A Case Report Of Gemcitabine-Induced Steatohepatitis Associated With Adjuvant Monotherapy For Pancreatic Adenocarcinoma, Maria Vershvovsky, Md, Dina Halegoua-De Marzio, Md

The Medicine Forum

Introduction:

Drug induced liver injury [DILI] is the most common cause of fulminant liver failure in the Western hemisphere. There are databases logging the myriad of herbs, supplements and medications that can cause DILI. Gemcitabine, a cytotoxic chemotherapy used most commonly in lung and pancreaticobiliary malignancy, has been well described as causing cholestatic liver injury. There are several case reports remarking on fatal hepatic failure with gemcitabine. This case describes steatohepatitis, a pattern of liver injury not previously described with gemcitabine.

Case Presentation:

This case involves a 51-year-old healthy Caucasian female who presented to her primary care physician with jaundice …