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Medical Specialties

Selected Works

1993

Articles 1 - 4 of 4

Full-Text Articles in Medicine and Health Sciences

Myocardial Alpha-Thrombin Receptor Activation Induces Hypertrophy And Increases Atrial Natriuretic Factor Gene Expression, C C. Glembotski, C E. Irons, K A. Krown, S F. Murray, A B. Sprenkle, C A. Sei Sep 1993

Myocardial Alpha-Thrombin Receptor Activation Induces Hypertrophy And Increases Atrial Natriuretic Factor Gene Expression, C C. Glembotski, C E. Irons, K A. Krown, S F. Murray, A B. Sprenkle, C A. Sei

Amy Sprenkle

The protease, a-thrombin (aTh), affects myocardial cell contractility, a feature common among agents that induce hypertrophy. However, it is not known whether cardiac myocytes possess aTh receptors (aTh-R), or if long term treatment with aTh can enhance growth and gene expression. In the present study primary neonatal rat ventricular myocytes expressed a 3.6-kilobase mRNA species that hybridized with a rat aTh-R-specific probe. After 48 h, aTh induced hypertrophy, sarcomeric organization, and enhanced atrial natriuretic factor (ANF) expression, all of which were blocked by the aTh-selective protease inhibitor, D-Phe-Pro-Argchloromethyl ketone. The aTh-R agonist peptide, SFLLRNPND, was a potent activator of ANF …

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Monocyte-Mediated Immunodepression After Acute Ethanol Exposure, Gyongyi Szabo Dec 1992

Monocyte-Mediated Immunodepression After Acute Ethanol Exposure, Gyongyi Szabo

Gyongyi Szabo

Szabo G. 1993. Monocyte-Mediated Immunodepression after Acute Ethanol Exposure. In Alcohol, Drugs of Abuse and Immunomodulation: proceedings of the 2nd International Conference on Alcohol, Drugs of Abuse and Immunomodulation (AIDS) held in Arizona, USA, on 9-13 September 1992. Advances in Biosciences, Vol. 86. Ed: R.R. Watson, Philadelphia, Pergamon Press, pp. 121-130. ISBN 0080420389, 9780080420387.

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Modulation Of Mhc Expression On Human Endothelial-Cells By Sera From Patients With Systemic Lupus-Erythematosus, Mary Anne Tan Jin Ai Dec 1992

Modulation Of Mhc Expression On Human Endothelial-Cells By Sera From Patients With Systemic Lupus-Erythematosus, Mary Anne Tan Jin Ai

Mary Anne Tan Jin Ai

Major histocompatibility complex (MHC) antigen expression on cells is a prerequisite for immune interaction with activated T-cells. This study examined the ability of sera from patients with systemic lupus erythematosus (SLE) to modulate MHC expression on vascular endothelial cells. SLE sera were able to selectively upregulate MHC class I antigen expression on cultured human umbilical venous endothelial (HUVE) cells, without concomitant induction of MHC class II antigen. The stimulation index (SI) for MHC class I expression produced by SLE sera (1.21 ± 0.23) was significantly higher than those for normal controls (1.01 ± 0.10) (P < 0.0001) and non-SLE patients (1.12 ± 0.14) (P < 0.05). Additionally, active SLE patients had higher mean SI than inactive patients (P < 0.001). Preincubation of SLE sera with Protein A-Sepharose beads conjugated with antibodies against tumor necrosis factor-α and interferon-α was able to significantly reduce their ability to upregulate class I MHC expression by HUVE cells, indicating that these cytokines were responsible for the modulatory effect. This could be an important mechanism for the immune-mediated vascular injury seen in SLE.

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Harpoon Extraction Of A Common Bile Duct Stone Impacted At The Ampulla Of Vater With Needle-Knife Sphincterotome., Vivian C. Mcalister, Andre Roy, Ron Passi Dec 1992

Harpoon Extraction Of A Common Bile Duct Stone Impacted At The Ampulla Of Vater With Needle-Knife Sphincterotome., Vivian C. Mcalister, Andre Roy, Ron Passi

Vivian C. McAlister

The urgency of dealing with impacted ampullary stones is underlined in the first case reported by Opie6 at the autopsy of a young woman. Impacted ampullary stones that prevent papillary cannulation and standard sphincterotomy make up less than 5% of common bile duct stones seen at ERCP.3 Several series suggest the safe use of needle-knife sphincterotomy to create a choledochoduodenal fistula or to allow subsequent standard sphincterotomy in this situation. These series have also reported failure to extract the stone so that surgical removal was required.3,4Successful sphincterotomy may facilitate the early diagnosis of tumors that cause the ampulla to bulge. …

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