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Full-Text Articles in Medicine and Health Sciences
Zona Pellucida-Induced Acrosome Reaction In Human Sperm: Dependency On Activation Of Pertussis Toxin-Sensitive G(I) Protein And Extracellular Calcium, And Priming Effect Of Progesterone And Follicular Fluid., Alessandro Schuffner, Hadley Bastiaan, E. Duran, Zin-Yong Lin, Mahmood Morshedi, Daniel Franken, Sergio Oehninger
Zona Pellucida-Induced Acrosome Reaction In Human Sperm: Dependency On Activation Of Pertussis Toxin-Sensitive G(I) Protein And Extracellular Calcium, And Priming Effect Of Progesterone And Follicular Fluid., Alessandro Schuffner, Hadley Bastiaan, E. Duran, Zin-Yong Lin, Mahmood Morshedi, Daniel Franken, Sergio Oehninger
Eyup Hakan Duran
In these studies, we aimed to characterize the effects of the physiological, homologous agonists of the acrosome reaction, i.e. the zona pellucida (ZP) and progesterone/follicular fluid, on human sperm. The specific aims of our studies were: (i) to examine the dependency of the solubilized ZP-induced acrosome reaction on G(i) protein activation and presence of extracellular calcium; and (ii) to determine whether progesterone/follicular fluid exert a priming or synergist effect on the solubilized ZP-induced acrosome reaction. Highly motile sperm from fertile donors were exposed to the agonists in a microassay and the acrosomal status of live sperm was determined by indirect …
The Association Of Reproductive Senescence With Mitochondrial Quantity, Function, And Dna Integrity In Human Oocytes At Different Stages Of Maturation., Eyup Duran, Fatma Simsek-Duran, Sergio Oehninger, Howard Jones, Frank Castora
The Association Of Reproductive Senescence With Mitochondrial Quantity, Function, And Dna Integrity In Human Oocytes At Different Stages Of Maturation., Eyup Duran, Fatma Simsek-Duran, Sergio Oehninger, Howard Jones, Frank Castora
Eyup Hakan Duran
OBJECTIVE: To determine the impact of reproductive aging on oocyte mitochondrial quantity, function, and DNA (mtDNA) integrity. DESIGN: Prospective observational study. SETTING: IVF clinic in a tertiary academic care center. PATIENT(S): One hundred two oocytes from 32 women undergoing IVF. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Adenosine triphosphate (ATP) levels, mtDNA number, and mtDNA deletion occurrence in individual oocytes. RESULT(S): Oocyte ATP content increases with maturation (786 ± 87 fmol, 1,037 ± 57 fmol, and 1,201 ± 59 fmol for prophase 1 [P1], metaphase 1 [M1], and metaphase 2 [M2] oocytes, respectively), whereas mtDNA copy numbers do not change (64,500 ± …
Optimization Of Dose And Image Quality For Computed Radiography And Digital Radiography, J. Aldrich, Eyup Duran, P. Dunlop, J. Mayo
Optimization Of Dose And Image Quality For Computed Radiography And Digital Radiography, J. Aldrich, Eyup Duran, P. Dunlop, J. Mayo
Eyup Hakan Duran
The surface doses to patients during chest, abdomen and pelvis radiography were measured over a period of 3 years, during which time computed radiography (CR) and digital radiography (DR) systems were introduced to replace film-screen systems. For film-screen and CR the surface doses were measured with thermoluminescent dosimeters. For DR the surface doses were calculated from the dose-area product (DAP) meter readings. Measurements were made for each type of examination and detector type on 10 average-size patients. Measurements were made immediately after the new systems were introduced, and subsequently as adjustments were made to optimize dose and image quality. Published …