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Full-Text Articles in Medicine and Health Sciences
Education Interventions To Prevent Readmission Of Heart Failure Patients, Emily Reed, Rebecca Schnepp
Education Interventions To Prevent Readmission Of Heart Failure Patients, Emily Reed, Rebecca Schnepp
Pharmacy and Nursing Student Research and Evidence-Based Medicine Poster Session
More than 5.7 billion people in United States have been diagnosed with heart failure (HF). Non-adherence to self-care measures necessary to manage HF is associated with exacerbation and readmission. A 27% 30-day readmission rate for Medicare patients with HF can lead to reduced Medicare payments and penalties. HF hospitalizations contribute to over half of the $39 million annual HF cost. Almost half of HF admits will be readmitted within six months of discharge. The purpose of this study is to determine the best heart failure discharge education content and method of delivery in order to promote patient self-care and prevent …
Regulation Of Protein Degradation In The Heart By Amp-Activated Protein Kinase, Kedryn K. Baskin
Regulation Of Protein Degradation In The Heart By Amp-Activated Protein Kinase, Kedryn K. Baskin
Dissertations & Theses (Open Access)
The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced through the ubiquitin proteasome system (UPS). Whether AMPK plays a role in protein degradation through the UPS in the heart is not known. Here I present data in support of the hypothesis that AMPK transcriptionally regulates key players in the UPS, which, under extreme conditions can be detrimental to the heart. The ubiquitin ligases MAFbx /Atrogin-1 and MuRF1, key regulators of …