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Full-Text Articles in Medicine and Health Sciences
Cardiac Acetylcholine Inhibits Ventricular Remodeling And Dysfunction Under Pathologic Conditions, Ashbeel Roy, Mouhamed Dakroub, Geisa C.S.V. Tezini, Yin Liu, Silvia Guatimosim, Qingping Feng, Helio C. Salgado, Vania F. Prado, Marco A.M. Prado, Robert Gros
Cardiac Acetylcholine Inhibits Ventricular Remodeling And Dysfunction Under Pathologic Conditions, Ashbeel Roy, Mouhamed Dakroub, Geisa C.S.V. Tezini, Yin Liu, Silvia Guatimosim, Qingping Feng, Helio C. Salgado, Vania F. Prado, Marco A.M. Prado, Robert Gros
Paediatrics Publications
Autonomic dysfunction is a characteristic of cardiac disease and decreased vagal activity is observed in heart failure. Rodent cardiomyocytes produce de novo ACh, which is critical in maintaining cardiac homeostasis. We report that this nonneuronal cholinergic system is also found in human cardiomyocytes, which expressed choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT). Furthermore, VAChT expression was increased 3- and 1.5-fold at the mRNA and protein level, respectively, in ventricular tissue from patients with heart failure, suggesting increased ACh secretion in disease. Weusedmicewith geneticdeletionof cardiomyocytespecificVAChTor ChATandmice overexpressingVAChT to test the functional significance of cholinergic signaling. Mice deficient for VAChT …
Cortisol And Testosterone In Hair As Biological Markers Of Systolic Heart Failure, Justin Chan
Cortisol And Testosterone In Hair As Biological Markers Of Systolic Heart Failure, Justin Chan
Electronic Thesis and Dissertation Repository
Congestive heart failure (CHF) is associated with increased stress and alterations in metabolism, favoring catabolism over anabolism. Hormonal profiles of patients with heart failure have been assessed using serum and saliva as matrices, which are only point measurements and do not provide long-term information. Scalp hair is a novel matrix that allows for measurement of hormones over a period of several months. We aimed to evaluate whether levels of cortisol and testosterone and their ratio (C/T) in hair correlate with severity of heart failure. We conducted a prospective study in ambulatory male patients with a left ventricular ejection fraction (LVEF) …