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Full-Text Articles in Medicine and Health Sciences
Methods And Animal Model For Analyzing Age-Related Macular Degeneration, Jayakrishna Ambati
Methods And Animal Model For Analyzing Age-Related Macular Degeneration, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
Methods for testing candidate drugs for treatment of age-related macular degeneration are provided. Ccl2-deficient, and Ccr2-deficient mice are used to determine the effect of candidate drugs and treatments on development of age-related macular degeneration. Also provided is a Ccl2-deficient, Ccr2-deficient dual knockout mouse, which is a useful animal model for age-related macular degeneration.
Vegf-A As An Inhibitor Of Angiogenesis And Methods Of Using Same, Jayakrishna Ambati
Vegf-A As An Inhibitor Of Angiogenesis And Methods Of Using Same, Jayakrishna Ambati
Ophthalmology and Visual Science Faculty Patents
The invention relates to methods and compositions for the treatment or prevention of ocular angiogenesis and neovascularization associated with neovascular disease. Administration of vascular endothelial growth factor (VEGF)-A into the eye when macrophage infiltration is reduced inhibits ocular angiogenesis.