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Full-Text Articles in Medicine and Health Sciences
Advanced Heart Failure Treatment Options Among The Elderly, German Guzman-Gutierrez, Yang Shi, Matthew Rappelt, Arshad Jahangir, Vinay Thohan
Advanced Heart Failure Treatment Options Among The Elderly, German Guzman-Gutierrez, Yang Shi, Matthew Rappelt, Arshad Jahangir, Vinay Thohan
Aurora Heart Failure / Transplant Faculty
The aging human population has emerged as a critically important factor in health care, not only due to the unique physiologic and pathologic processes associated with aging but also because of the evolution of medical and surgical therapies that have increased quality and quantity of life. Heart failure is a disease found most commonly among older populations in whom it is associated with high morbidity and mortality. Heart failure disproportionately affects the elderly, and it stands to reason that the most terminal stage, known as advanced heart failure (AHF), is more common among the elderly. Despite limited data, treatment options …
Atrial Fibrillation And Stroke In Elderly Patients, Geetanjali Dang, Imaan Jahangir, Jasbir Sra, A. Jamil Tajik, Arshad Jahangir
Atrial Fibrillation And Stroke In Elderly Patients, Geetanjali Dang, Imaan Jahangir, Jasbir Sra, A. Jamil Tajik, Arshad Jahangir
Jasbir Sra, MD, FACC, Program Director
The increasing prevalence of stroke, with an estimated annual cost of $71.5 billion, has made it a major health problem that increases disability and death, particularly in patients with atrial fibrillation. Although advanced age and atrial fibrillation are recognized as strong risk factors for stroke, the basis for this susceptibility are not well defined. Aging or associated diseases are accompanied by changes in rheostatic, humoral, metabolic and hemodynamic factors that may contribute more to stroke predisposition than rhythm abnormality alone. Several thromboembolism-predisposing clinical characteristics and serum biomarkers with prognostic significance have been identified in patients with atrial fibrillation. Although anticoagulation …
Impaired Skeletal Muscle Blood Flow Control With Advancing Age In Humans: Attenuated Atp Release And Local Vasodilation During Erythrocyte Deoxygenation, Brett S. Kirby, Anne R. Crecelius, Wyatt F. Voyles, Frank A. Dinenno
Impaired Skeletal Muscle Blood Flow Control With Advancing Age In Humans: Attenuated Atp Release And Local Vasodilation During Erythrocyte Deoxygenation, Brett S. Kirby, Anne R. Crecelius, Wyatt F. Voyles, Frank A. Dinenno
Anne R. Crecelius
Rationale: Skeletal muscle blood flow is coupled with the oxygenation state of hemoglobin in young adults, whereby the erythrocyte functions as an oxygen sensor and releases ATP during deoxygenation to evoke vasodilation. Whether this function is impaired in humans of advanced age is unknown. Objective: To test the hypothesis that older adults demonstrate impaired muscle blood flow and lower intravascular ATP during conditions of erythrocyte deoxygenation. Methods and Results: We showed impaired forearm blood flow responses during 2 conditions of erythrocyte deoxygenation (systemic hypoxia and graded handgrip exercise) with age, which was caused by reduced local vasodilation. In young adults, …
Healthy Aging In Massachusetts: Reporting Indicators, Identifying Resources & Activating Allies, Elizabeth Dugan, Frank Porell, Nina Silverstein, Ruth Palombo, Chae Man Lee, Kristina Turk
Healthy Aging In Massachusetts: Reporting Indicators, Identifying Resources & Activating Allies, Elizabeth Dugan, Frank Porell, Nina Silverstein, Ruth Palombo, Chae Man Lee, Kristina Turk
Frank Porell
In Massachusetts, a Healthy Aging Collaborative comprised of a diverse group of stakeholders has been formed for multiple purposes: information sharing around healthy aging, idea generation, partnership building and activity mapping.
Healthy Aging In Massachusetts: Reporting Indicators, Identifying Resources & Activating Allies, Elizabeth Dugan, Frank Porell, Nina Silverstein, Ruth Palombo, Chae Man Lee, Kristina Turk
Healthy Aging In Massachusetts: Reporting Indicators, Identifying Resources & Activating Allies, Elizabeth Dugan, Frank Porell, Nina Silverstein, Ruth Palombo, Chae Man Lee, Kristina Turk
Elizabeth Dugan
In Massachusetts, a Healthy Aging Collaborative comprised of a diverse group of stakeholders has been formed for multiple purposes: information sharing around healthy aging, idea generation, partnership building and activity mapping.
Effects Of Aging On Pressure-Induced Mapk Activation In The Rat Aorta, Kevin M. Rice
Effects Of Aging On Pressure-Induced Mapk Activation In The Rat Aorta, Kevin M. Rice
Kevin M Rice
With age, the cardiovascular system experiences substantial alterations in cellular morphology and function. The factors regulating these changes are unknown; however, the mitogen activated protein kinase (MAPK) pathways have emerged as critical components for mediating numerous cellular responses including control of cell growth, differentiation and adaptation. Here we compare the expression, basal activation and the ability of increased pressure to activate the MAPK pathways in adult (6 month old), aged (30 month old) and very aged (36 month old) Fischer 344 x Brown Norway F1 Hybrid rats. Histochemical analysis demonstrated an age-related increase in tunica media thickness of approximately 11% …
Risk Of Premature Stroke In Recent Immigrants (Presario): Population-Based Matched Cohort Study., Gustavo Saposnik
Risk Of Premature Stroke In Recent Immigrants (Presario): Population-Based Matched Cohort Study., Gustavo Saposnik
Gustavo Saposnik
No abstract provided.
Myocardial Infarction Associated With Recency Of Immigration To Ontario., Gustavo Saposnik
Myocardial Infarction Associated With Recency Of Immigration To Ontario., Gustavo Saposnik
Gustavo Saposnik
No abstract provided.
Stroke In The Very Elderly: Hospital Care, Case Fatality And Disposition., Gustavo Saposnik
Stroke In The Very Elderly: Hospital Care, Case Fatality And Disposition., Gustavo Saposnik
Gustavo Saposnik
No abstract provided.
Age Disparities In Stroke Quality Of Care And Delivery Of Health Services., Gustavo Saposnik
Age Disparities In Stroke Quality Of Care And Delivery Of Health Services., Gustavo Saposnik
Gustavo Saposnik
No abstract provided.
Do All Age Groups Benefit From Organized Inpatient Stroke Care?, Gustavo Saposnik
Do All Age Groups Benefit From Organized Inpatient Stroke Care?, Gustavo Saposnik
Gustavo Saposnik
No abstract provided.
Stroke Outcome In Those Over 80: A Multicenter Cohort Study Across Canada., Gustavo Saposnik
Stroke Outcome In Those Over 80: A Multicenter Cohort Study Across Canada., Gustavo Saposnik
Gustavo Saposnik
No abstract provided.