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2019

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Full-Text Articles in Medicine and Health Sciences

Week Of December 16, 2019, New York Medical College Dec 2019

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Week Of June 11, 2019, New York Medical College

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Ephb-Ephrinb Cis Interaction Regulates Filopodial Movement, Yu-Ting Mao, Matthew B. Dalva Jun 2019

Ephb-Ephrinb Cis Interaction Regulates Filopodial Movement, Yu-Ting Mao, Matthew B. Dalva

Department of Neuroscience Posters

Neural connections are initiated by motile dendritic and axonal protrusions, such as dendritic filopodia and axonal growth cones. Dendritic filopodia interview many axons and then choose the correct ones to make stable contacts. Specific rates of EphB activation in dendritic filopodia controls the decision of filopodia to reject or stabilize a synaptic contact onto an axon. However, it remains unknown how EphB activity in dendritic filopodia is modulated to regulate filopodial decisions. Here using an optogenetic approach, we find that photoactivation of a cis-interaction between EphB2 and ephrinB3 prevents filopodial retraction, likely driving filopodial stabilization. Using photoactivatable EphB2KD as a …


Week Of June 3, 2019, New York Medical College Jun 2019

Week Of May 28, 2019, New York Medical College May 2019

Week Of May 20, 2019, New York Medical College May 2019

Week Of May 13, 2019, New York Medical College May 2019

Week Of May 6, 2019, New York Medical College May 2019

Week Of May 6, 2019, New York Medical College

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Prospective Evaluation Of A Population Pharmacokinetic Model Of Pantoprazole For Obese Children, Alenka Chapron, Susan M. Abdel-Rahman, Valentina Shakhnovich May 2019

Prospective Evaluation Of A Population Pharmacokinetic Model Of Pantoprazole For Obese Children, Alenka Chapron, Susan M. Abdel-Rahman, Valentina Shakhnovich

Posters

We previously developed a population pharmacokinetic (popPK) model of pantoprazole for obese children. Our objective was to evaluate the predictive performance of this model in an independent cohort of normal weight, overweight and obese children.


The Physiology And Hormonal Control Of Calcium, Phosphate And Vitamin D, Uri Alon May 2019

The Physiology And Hormonal Control Of Calcium, Phosphate And Vitamin D, Uri Alon

Presentations

Describes calcium, phophate, and vitamin D in the context of pediatric rickets.


The Effect Of Antihypertensive Dosing On Hypertension In Children With Chronic Kidney Disease, Benjamin A. Matta, Uri S. Alon, Tarak Srivastava, Bradley A. Warady, Darcy Weidemann May 2019

The Effect Of Antihypertensive Dosing On Hypertension In Children With Chronic Kidney Disease, Benjamin A. Matta, Uri S. Alon, Tarak Srivastava, Bradley A. Warady, Darcy Weidemann

Posters

This study's objective was to determine the effect of antihypertensive dose on hypertension status in children with chronic kidney disease. This was the first quantitative analysis of antihypertensive dose expressed as a newly developed measure, cDDI, and is relationship with hypertension status in children with CKD.


Neuroblastoma In Adolescents And Children Older Than 10 Years: Unusual Clinicopathologic And Biologic Features, Laura Mccarthy, Katherine Chastain, Terrie Flatt, Eugenio Taboada, Robert E. Garola, John Herriges, Linda D. Cooley, Atif Ahmed May 2019

Neuroblastoma In Adolescents And Children Older Than 10 Years: Unusual Clinicopathologic And Biologic Features, Laura Mccarthy, Katherine Chastain, Terrie Flatt, Eugenio Taboada, Robert E. Garola, John Herriges, Linda D. Cooley, Atif Ahmed

Posters

This poster describes four cases of neuroblastoma diagnosed since 2008 in children greater than 10 years and presents their clinical, histologic and biologic features, emphasizing unusual clinicopathologic characteristics and the role of DNA microarray analysis and Next Generation Sequencing in their management.


Viral Whole Genome Sequencing For Antiviral Resistance In A Child With Dock8 Deficiency And Recurrent Hsv-1, Sean Stout, A. L. Greninger, Rangaraj Selvarangan, A. F. Freeman, Brandon D. Newell, Erin Stahl, Dwight Yin May 2019

Viral Whole Genome Sequencing For Antiviral Resistance In A Child With Dock8 Deficiency And Recurrent Hsv-1, Sean Stout, A. L. Greninger, Rangaraj Selvarangan, A. F. Freeman, Brandon D. Newell, Erin Stahl, Dwight Yin

Posters

We present the case of a child with dedicator of cytokinesis 8 (DOCK8) deficiency and chronic, resistant HSV-1 mucocutaneous infections to illustrate the clinical utility of viral whole genome sequencing to detect active and latent HSV resistance mutations.


Predictive Performance Of Existing Population Pharmacokinetic Models Of Tacrolimus In Pediatric Kidney Transplant Recipients, Alenka Chapron, Susan M. Abdel-Rahman May 2019

Predictive Performance Of Existing Population Pharmacokinetic Models Of Tacrolimus In Pediatric Kidney Transplant Recipients, Alenka Chapron, Susan M. Abdel-Rahman

Posters

With the goal of developing a clinician-driven tacrolimus (TAC) pharmacokinetic dosing tool, our initial objectives were 1) to examine whether published TAC population pharmacokinetic (popPK) models could serve as a foundation for the dosing tool, and 2) evaluate their performance predicting TAC concentrations in an independent cohort of Children's Mercy patients.


Week Of April 29, 2019, New York Medical College Apr 2019