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Full-Text Articles in Medicine and Health Sciences
Tlr2 (-196 To -174 Ins/Del) And Tlr3 (1377c>T) As Biomarkers For Nasopharyngeal Cancer In Tunisia, Lamia Makni, Amira Messadi, Sabrina Zidi, Ezzedine Gazouani, Amel Mezlini, Besma Yacoubi-Loueslati
Tlr2 (-196 To -174 Ins/Del) And Tlr3 (1377c>T) As Biomarkers For Nasopharyngeal Cancer In Tunisia, Lamia Makni, Amira Messadi, Sabrina Zidi, Ezzedine Gazouani, Amel Mezlini, Besma Yacoubi-Loueslati
Turkish Journal of Medical Sciences
Background/aim: We evaluated the association of TLR2 (-196 to -174 Ins/Del) and TLR3 (1377 C>T) as potential risk factors for nasopharyngeal carcinoma (NPC) in Tunisians. Material and methods: The study subjects comprised 137 NPC patients and 164 cancer-free control subjects. TLR2 genotyping was done by PCR and TLR3 genotyping was performed by PCR-RFLP. Results: Minor allele frequency (MAF) and genotypes of TLR3 (1377 C>T) were comparable between NPC patients and controls. Significantly higher MAF and TLR2-containing Del allele genotypes of TLR2 (-196 to -174 Ins/Del) were seen in NPC patients compared to controls [OR (95% CI) = 2.10 …
Xenobiotic/Drug Metabolizing Enzyme And Tp53 Polymorphisms And Clinical Outcomein Advanced Nonsmall Cell Lung Cancer Patients, Volkan Karacaoğlan, Ahmet Oğuz Ada, Serdar Bi̇lgen, Güzi̇de Tuğba Çeti̇nkaya, Emre Soydaş, Celaletti̇n Semi̇h Kunak, Si̇bel Meryem Alpar, Meral Gülhan, Mümtaz İşcan
Xenobiotic/Drug Metabolizing Enzyme And Tp53 Polymorphisms And Clinical Outcomein Advanced Nonsmall Cell Lung Cancer Patients, Volkan Karacaoğlan, Ahmet Oğuz Ada, Serdar Bi̇lgen, Güzi̇de Tuğba Çeti̇nkaya, Emre Soydaş, Celaletti̇n Semi̇h Kunak, Si̇bel Meryem Alpar, Meral Gülhan, Mümtaz İşcan
Turkish Journal of Medical Sciences
Background/aim: The association between polymorphisms of xenobiotic/drug metabolizing enzymes and TP53 and response to chemotherapy and survival of patients with nonsmall cell lung cancer (NSCLC) are limited and inconclusive. In this study, CYP2E1*5B, CYP2E1*6, CYP2E1*7B, GSTO1 (A140D), and TP53 (Arg72Pro) polymorphisms and response to platinum-based chemotherapy and survival in 137 advanced stage NSCLC patients were investigated. Materials and methods: Genetic polymorphism analyses were determined by polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP). Results: The patients with TP53 Pro/Pro variant were more likely to be resistant to chemotherapy than those with Arg/Arg variants with marginal significance (P …
Polymorphisms Of Cancer-Related Genes And Risk Of Multipleprimary Malignancies Involving Colorectal Cancer, Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo
Polymorphisms Of Cancer-Related Genes And Risk Of Multipleprimary Malignancies Involving Colorectal Cancer, Peiguo Cao, Li Yu, Anshan Wu, Jingjing Li, Ling Liu, Chunlan Liu, Jianda Zhou, Ke Cao, Chengxian Guo
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of cancer-related genes and the risk of multiple primary malignancies involving colorectal cancer.Materials and methods: We collected tissue samples from 22 multiple primary cancer patients with primary colorectal cancer and performed genotyping assay for 116 SNP loci from 62 genes encoding peptides functioning in various signaling pathways using the DNA MassARRAY system. The chi-square test was used to compare the differences in base frequencies between patients and a control Chinese population from HapMap through the NCBI database.Results: No significant differences in frequencies were detected for 81 SNPs …