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2015

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Full-Text Articles in Medicine and Health Sciences

Week Of December 14, 2015, New York Medical College Dec 2015

Progtar: A Database Of Prognostically Inversely Correlated Mirnas And Genes (Pics) In Multiple Cancers, Chirayu Pankaj Goswami Dec 2015

Progtar: A Database Of Prognostically Inversely Correlated Mirnas And Genes (Pics) In Multiple Cancers, Chirayu Pankaj Goswami

Department of Pathology, Anatomy, and Cell Biology Posters

ABSTRACT

PROGTar is a database of Prognostically Inversely Correlated miRNA-mRNA pairs (PIC’s) in 23 cancer types. Partner miRNA and mRNA in a PIC show inverse correlation of expression and opposite hazards. We analyzed miRNA and mRNA expression data downloaded from The Cancer Genome Atlas (TCGA) in a 3 step approach to identify PICs in different cancer types. In first step we performed correlation analysis between miRNAs and mRNAs for each cancer type. This was followed by performing hazard analysis separately for miRNAs and mRNAs using expression data and survival related clinical variables. In the third step we merged the correlation …


Week Of December 7, 2015, New York Medical College Dec 2015

Week Of November 16, 2015, New York Medical College Nov 2015

Week Of November 9, 2015, New York Medical College Nov 2015

A Phase I Study Of Ad5-Gucy2c-Padre In Stage I And Ii Colon Cancer Patients, Adam E. Snook, Trevor R. Baybutt, Michael J. Mastrangelo, Nancy L. Lewis, Scott D. Goldstein, Walter K. Kraft, Yaa D. Oppong, Terry Hyslop, Ronald E. Myers, Vitali Alexeev, Laurence C. Eisenlohr, Takami Sato, Scott A. Waldman Nov 2015

A Phase I Study Of Ad5-Gucy2c-Padre In Stage I And Ii Colon Cancer Patients, Adam E. Snook, Trevor R. Baybutt, Michael J. Mastrangelo, Nancy L. Lewis, Scott D. Goldstein, Walter K. Kraft, Yaa D. Oppong, Terry Hyslop, Ronald E. Myers, Vitali Alexeev, Laurence C. Eisenlohr, Takami Sato, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Posters

Background

Ad5-GUCY2C-PADRE is a replication-deficient human type 5 recombinant adenovirus (Ad5) vaccine encoding guanylyl cyclase C (GUCY2C) fused to the PAn DR Epitope (PADRE). GUCY2C, a paracrine hormone receptor producing the second messenger cyclic GMP (cGMP), is selectively expressed by intestinal epithelial cells and a subset of hypothalamic neurons, but not other tissues. Importantly, GUCY2C is over-expressed in nearly all primary and metastatic human colorectal tumors. Preclinical studies in mice demonstrated selective tolerance of GUCY2C-specific CD4+ T cells, but not CD8+ T or B cells, necessitating inclusion of the exogenous CD4+ T helper cell epitope PADRE to maximize GUCY2C-specific CD8+ …


Week Of November 2, 2015, New York Medical College Nov 2015

Week Of October 26, 2015, New York Medical College Oct 2015

Week Of October 19, 2015, New York Medical College Oct 2015

Week Of October 5, 2015, New York Medical College Oct 2015

We Are… Bridging Medicine And Science, Vol. 1, Issue 4, Fall 2015, Marshall University Biomedical Sciences Oct 2015

We Are… Bridging Medicine And Science, Vol. 1, Issue 4, Fall 2015, Marshall University Biomedical Sciences

We Are... Bridging Medicine Science

No abstract provided.


Week Of September 28, 2015, New York Medical College Sep 2015

Week Of September 14, 2015, New York Medical College Sep 2015

Week Of September 8, 2015, New York Medical College Sep 2015

Week Of August 31, 2015, New York Medical College Aug 2015

Week Of August 24, 2015, New York Medical College Aug 2015

Week Of July 27, 2015, New York Medical College Jul 2015

Week Of June 29, 2015, New York Medical College Jun 2015

Week Of June 1, 2015, New York Medical College Jun 2015

Week Of May 18, 2015, New York Medical College May 2015

Week Of May 11, 2015, New York Medical College May 2015

Week Of April 27, 2015, New York Medical College Apr 2015

Week Of April 20, 2015, New York Medical College Apr 2015

Proceedings - Wright State University Boonshoft School Of Medicine Seventh Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine Apr 2015

Proceedings - Wright State University Boonshoft School Of Medicine Seventh Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine

Medical Student Research Symposium Proceedings

The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Seventh Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 8, 2015.


Developing Burrowing As A Non-Evoked Readout Assessment For Novel Analgesic Drug Efficacy, Kayla Lindros, Denise Giuvelis, Ed Bilsky Mar 2015

Developing Burrowing As A Non-Evoked Readout Assessment For Novel Analgesic Drug Efficacy, Kayla Lindros, Denise Giuvelis, Ed Bilsky

Neuroscience Student Research Posters

Traditional drug development efforts to diminish the problem of chronic pain rely heavily on pain-evoked assays that can yield false positives, leading to confounding assessments of novel drugs. To avoid this, we are looking at burrowing as a novel readout assessment of analgesic efficacy. Preliminary data shows that induction of post-surgical pain reduces this innate behavior by about 35%. In attempt to increase this number, we tested a variety of additional parameters. Blue pads, placed at the bottom of each chamber in order to reduce the sound made when gravel is displaced, increased baseline amounts roughly 40%. Conversely, neither sex …


Fusion, 2015, George Washington University, William H. Beaumont Medical Research Honor Society Jan 2015

Fusion, 2015, George Washington University, William H. Beaumont Medical Research Honor Society

Fusion

No abstract provided.


The Metabolism Of Alcohol: Risk And Protective Factors, Sydney E. Levan, Amy Adkins, Danielle Dick, Karen G. Chartier Jan 2015

The Metabolism Of Alcohol: Risk And Protective Factors, Sydney E. Levan, Amy Adkins, Danielle Dick, Karen G. Chartier

Undergraduate Research Posters

Purpose: Abstract for poster submission to VCU Poster Symposium for

Undergraduate Research and Creativity

Title: The Metabolism of Alcohol: Risk and Protective Factors

Background: In 2002, it was reported by the National Institutes of Health that

60.3% of college aged students (18-22) drank alcohol in the past month of being

asked, as compared to 51.9% of those not in college. They also found that 20% of

college students met the criteria for at least one alcohol use disorder (AUDs)1.

Many genes have been linked to an increased risk for AUDs and how individuals

with various ethnic backgrounds respond to alcohol. …


Use Of Oxytocin As A Preventative Treatment For Ptsd, Laurel V. Kovalchick Jan 2015

Use Of Oxytocin As A Preventative Treatment For Ptsd, Laurel V. Kovalchick

Undergraduate Research Posters

Posttraumatic stress disorder (PTSD) is a mental health disorder triggered by experiencing a traumatic event. PTSD causes recurrent flashbacks of traumatic memories that lead to over-consolidation. Memory over-consolidation prevents extinction of emotional and physiological responses to the memory. Because individuals can respond differently to stress and frightening experiences, no measures are currently practiced to prevent PTSD. By studying the changes in the brain during PTSD and after stress, it can be hypothesized that treatments that regulated HPA axis activity may prevent PTSD symptoms if applied soon after stress. Risk of developing PTSD is associated with abnormal cortisol and norepinephrine levels …


Amla Enhances Autophagy And Modulates Beta Amyloid Metabolism In An In Vitro Model Of Alzheimer’S Disease, Elham Teimouri, Prashant Bharadwaj, Stephanie R. Rainey-Smith, Paul Fraser, Giuseppe Verdile, Ralph N. Martins Jan 2015

Amla Enhances Autophagy And Modulates Beta Amyloid Metabolism In An In Vitro Model Of Alzheimer’S Disease, Elham Teimouri, Prashant Bharadwaj, Stephanie R. Rainey-Smith, Paul Fraser, Giuseppe Verdile, Ralph N. Martins

ECU Posters

Alzheimer’s disease (AD) is a progressive, fatal neurodegenerative disease characterized by extensive neuronal loss associated with increased accumulation of the beta amyloid (Aβ) protein. Reducing production, preventing aggregation and improving clearance of Aβare areas of active research in the development of therapeutic agents to ameliorate neurodegeneration in AD. The Indian plant amla (Emblicaofficinalis), commonly known as Indian gooseberry, has widely been utilized in traditional Ayurvedic medicine preparations in the treatment of a variety of disease conditions including cardiovascular disease and diabetes: accumulating evidence also suggests that amla may be beneficial in AD. Amla exhibits antioxidant, anti-inflammatory, and anti-apoptotic mechanisms and …


Feasibility Of Integrating Tripterygium Wilfordii Into Modern Cancer Therapy For Increased Efficacy And Minimal Toxicity, Ngoc T. Vo Jan 2015

Feasibility Of Integrating Tripterygium Wilfordii Into Modern Cancer Therapy For Increased Efficacy And Minimal Toxicity, Ngoc T. Vo

Undergraduate Research Posters

Cancer is the second leading cause of death in the U.S. and millions of novel cancer cases are being diagnosed each year. While chemotherapy and ionizing radiation are effective treatments against these malignant tumors, the adverse effects that accompany such treatments are devastating. In order to find alternative treatment methods with less side effects, we turn to Eastern herbal medicine. Recent scientific research has found that Tripterygium wilfordii, an herbal medicine traditionally used to treat inflammation in China, contains compounds (triptolide and celastrol) that prevent the growth of solid tumors, induce apoptosis, and prevent metastasis of developed tumors. Investigations …