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Kinetic Analysis Of Dynamic Pet For Molecular, Functional And Physiological Characterization Of Diseases, Fiona Li

Electronic Thesis and Dissertation Repository

PET with targeted probes may better elucidate the molecular and functional basis of diseases. The widely used standardized uptake value from static imaging, however, cannot quantify the probe uptake processes like perfusion, permeability, binding to and disassociation (k₄) from target. The overarching thesis goal is to develop a model to enable kinetic analysis of dynamic imaging to separate these processes.

As perfusion delivery is not modelled in the current standard two tissue compartment (S2TC) model, I developed a flow modified two tissue compartment (F2TC) model that incorporates the blood flow effect. The model’s performances were investigated with simulation. …