Open Access. Powered by Scholars. Published by Universities.®
- Keyword
- Publication
- Publication Type
Articles 1 - 10 of 10
Full-Text Articles in Medicine and Health Sciences
Caenorhabditis Briggsae Recombinant Inbred Line Genotypes Reveal Inter-Strain Incompatibility And The Evolution Of Recombination, Joseph A. Ross, Daniel C. Koboldt, Julia E. Staisch, Helen M. Chamberlin, Bhagwati P. Gupta, Raymond D. Miller, Scott Everet Baird, Eric S. Haag
Caenorhabditis Briggsae Recombinant Inbred Line Genotypes Reveal Inter-Strain Incompatibility And The Evolution Of Recombination, Joseph A. Ross, Daniel C. Koboldt, Julia E. Staisch, Helen M. Chamberlin, Bhagwati P. Gupta, Raymond D. Miller, Scott Everet Baird, Eric S. Haag
Biological Sciences Faculty Publications
The nematode Caenorhabditis briggsae is an emerging model organism that allows evolutionary comparisons with C. elegans and exploration of its own unique biological attributes. To produce a high-resolution C. briggsae recombination map, recombinant inbred lines were generated from reciprocal crosses between two strains and genotyped at over 1,000 loci. A second set of recombinant inbred lines involving a third strain was also genotyped at lower resolution. The resulting recombination maps exhibit discrete domains of high and low recombination, as in C. elegans, indicating these are a general feature of Caenorhabditis species. The proportion of a chromosome's physical size occupied by …
The Effect Of Training On Motoneuron Survival In Amyotrophic Lateral Sclerosis: Which Motoneuron Type Is Saved?, Sherif M. Elbasiouny, Jenna E. Schuster
The Effect Of Training On Motoneuron Survival In Amyotrophic Lateral Sclerosis: Which Motoneuron Type Is Saved?, Sherif M. Elbasiouny, Jenna E. Schuster
Neuroscience, Cell Biology & Physiology Faculty Publications
Amyotrophic lateral sclerosis (ALS) is characterized by selective and progressive degeneration of motoneurons (MNs). Although the etiology of the disease is unknown, glutamate toxicity and reactive oxygen species toxicity have been strongly implicated in ALS pathophysiology, Training exercise has been proposed to provide a beneficial therapy during the early or late stages of ALS; however, some studies showed deleterious effects of exercise on survival in ALS.
Proceedings - Wright State University Boonshoft School Of Medicine Third Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine
Proceedings - Wright State University Boonshoft School Of Medicine Third Annual Medical Student Research Symposium: Celebrating Medical Student Scholarship, Office Of Research Affairs, Boonshoft School Of Medicine
Medical Student Research Symposium Proceedings
The student abstract booklet is a compilation of abstracts from students' oral and poster presentations at Wright State University's Third Annual Boonshoft School of Medicine Medical Student Research Symposium held on April 21, 2011.
Avian Community Ecology And The Shifting Baseline In Sugarcreek Metropark, Jennifer Lynne Hays, Thomas P. Rooney, Jeffrey L. Peters
Avian Community Ecology And The Shifting Baseline In Sugarcreek Metropark, Jennifer Lynne Hays, Thomas P. Rooney, Jeffrey L. Peters
Biological Sciences Faculty Publications
No abstract provided.
Abundance And Trends Of Woodpecker Populations In The Wright State Biology Preserve, Brittany Damron, Thomas P. Rooney
Abundance And Trends Of Woodpecker Populations In The Wright State Biology Preserve, Brittany Damron, Thomas P. Rooney
Biological Sciences Faculty Publications
No abstract provided.
Carbon Sequestration In Soils Of The Wright State University Biology Preserve, Laurie Wissler, Thomas P. Rooney
Carbon Sequestration In Soils Of The Wright State University Biology Preserve, Laurie Wissler, Thomas P. Rooney
Biological Sciences Faculty Publications
No abstract provided.
Activation Of The Basolateral Membrane Cl- Conductance Essential For Electrogenic K+ Secretion Suppresses Electrogenic Cl- Secretion, Quanhua He, Susan T. Halm, Jin Zhang, Dan R. Halm
Activation Of The Basolateral Membrane Cl- Conductance Essential For Electrogenic K+ Secretion Suppresses Electrogenic Cl- Secretion, Quanhua He, Susan T. Halm, Jin Zhang, Dan R. Halm
Neuroscience, Cell Biology & Physiology Faculty Publications
Adrenaline activates transient Cl--secretion and sustained K+-secretion across isolated distal colonic mucosa of guinea pig. The Ca++-activated Cl- channel inhibitor CaCCinh-A01 [30μM] significantly reduced electrogenic K+-secretion, detected as short-circuit current (Isc). This inhibition supported the cell model for K+-secretion in which basolateral membrane Cl- channels provide an exit pathway for Cl- entering the cell via Na+/K+/2Cl--cotransporters. CaCCinh-A01 inhibited both Isc and transepithelial conductance in a concentration dependent manner, IC50 = 6.3 μM. GlyH-101, another Cl- channel …
Effects Of Xs® Energy Drink On Aerobic Exercise Capacity Of Athletes, Kevin M. Sheehan, Lynn K. Hartzler
Effects Of Xs® Energy Drink On Aerobic Exercise Capacity Of Athletes, Kevin M. Sheehan, Lynn K. Hartzler
Biological Sciences Faculty Publications
A small increase in performance is often the difference between winning and losing for athletes, and energy supplements are marketed to give them a competitive edge. One such supplement is XS® Energy Drink which contains B vitamins, caffeine, taurine, and an herbal adaptogen blend. XS® Energy Drink is primarily designed and marketed as an alertness stimulus; however, it is also marketed to athletes as a performance enhancing supplement. The hypothesis of this investigation was that the consumption of XS® Energy Drink before exercise would increase aerobic capacity (an increase in Vo2max) and time to fatigue, and would decrease time for …
Perinatal Or Adult Nf1 Inactivation Using Tamoxifen-Inducible Plpcre Each Cause Neurofibroma Formation, Debra A. Mayes, Tilat A. Rizvi, Jose A. Cancelas, Nathan T. Kolasinski, Georgianne M. Ciraolo, Anat O. Stemmer-Rachamimov, Nancy Ratner
Perinatal Or Adult Nf1 Inactivation Using Tamoxifen-Inducible Plpcre Each Cause Neurofibroma Formation, Debra A. Mayes, Tilat A. Rizvi, Jose A. Cancelas, Nathan T. Kolasinski, Georgianne M. Ciraolo, Anat O. Stemmer-Rachamimov, Nancy Ratner
Neuroscience, Cell Biology & Physiology Faculty Publications
OBJECTIVES
Neurofibromas are tumors initiated by biallelic mutation of the NF1 tumor suppressor gene in the Schwann cell lineage. One idea within the field suggests that Nf1loss must occur within progenitor cells present within a critical window during Schwann cell development in order for neurofibromas to form. To test this hypothesis and to examine whethermyelinating Schwann cells can serve as aneurofibroma cell of origin, Nf1 loss was induced at perinatal or adult timepoints using a tamoxifen-inducible Plp-CreERT driver.
RESULTS
Perinatal loss of Nf1 resulted in small neurofibromas late in life, while adult loss caused large neurofibromas and morbidity beginning …
How Loss Of Neurofibromin In Oligodendrocytes Affects The Brain, Debra A. Mayes, Tilat A. Rizvi, Nathan T. Kolasinski, S. Miller, Nancy Ratner
How Loss Of Neurofibromin In Oligodendrocytes Affects The Brain, Debra A. Mayes, Tilat A. Rizvi, Nathan T. Kolasinski, S. Miller, Nancy Ratner
Neuroscience, Cell Biology & Physiology Faculty Publications
Neurofibromatosis type 1 patients are predisposed to central nervous system (CNS) phenotypes including enlarged brains, delayed acquisition of motor skills, brain tumors, and cognitive deficits. Imaging and pathologic analysis suggest that changes in white matter myelination may underlie both the enlargement of white matter tracts that contributes to megancephaly, and/or hyper-intense signals visualized on MRI. To study the role(s) of Nf1 and HRasin oligodendrocytes, we examined the optic nerve and corpus callosum,myelinated fiber tracts.We studiedNf1heterozygous mice,tamoxifen-induced Nf1 loss in mature oligodendrocytes (Plp-CreERT), and a new transgenic model in which the CNPase promoter drives expression of HRasG12V. Activated HRas and loss …