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Administration Of Intranasal Insulin During Cardiopulmonary Resuscitation Improves Neurological Outcomes After Cardiac Arrest, Adam D. Chalek, Tulasi R. Jinka, Kathleen J. Maheras, Joseph M. Wider, Sarita Raghunayakula, Jinhui Liao, Amanda Qvigstad, Anthony R. Anzell, Erin Gruley, Xiaodan Ren, Rui Zhang, Robert W. Neumar, Thomas H. Sanderson
Administration Of Intranasal Insulin During Cardiopulmonary Resuscitation Improves Neurological Outcomes After Cardiac Arrest, Adam D. Chalek, Tulasi R. Jinka, Kathleen J. Maheras, Joseph M. Wider, Sarita Raghunayakula, Jinhui Liao, Amanda Qvigstad, Anthony R. Anzell, Erin Gruley, Xiaodan Ren, Rui Zhang, Robert W. Neumar, Thomas H. Sanderson
Medical Student Research Symposium
INTRODUCTION: Over 325,000 people die from cardiac arrest each year. Prognosis is poor and survivors typically experience persistent neurologic deficits. Currently, neuroprotective treatments to reduce brain injury in cardiac arrest survivors are limited and ineffective. This study evaluates the potential neuroprotection induced by high dose intranasal insulin (HD-IN-I) in a rodent model of asphyxial cardiac arrest.
METHODS: Male Long Evans rats were block randomized to sham-operated controls or 8-minute asphyxial cardiac arrest treated with placebo or HD-IN-I at the onset of CPR. To investigate mechanism of action, hippocampi were collected 30 minutes post-ROSC and analyzed by Western blot for phosphorylation …