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Open Access. Powered by Scholars. Published by Universities.®

Medical Sciences

University of South Carolina

2015

Articles 1 - 7 of 7

Full-Text Articles in Medicine and Health Sciences

The Adaptive Change Of Hla-Drb1 Allele Frequencies Caused By Natural Selection In A Mongolian Population That Migrated To The South Of China, Hao Sun, Zhaoqing Yang, Keqin Lin, Shuyuan Liu, Kai Huang, Xiuyun Wang, Jiayou Chu, Xinyu Huang Jul 2015

The Adaptive Change Of Hla-Drb1 Allele Frequencies Caused By Natural Selection In A Mongolian Population That Migrated To The South Of China, Hao Sun, Zhaoqing Yang, Keqin Lin, Shuyuan Liu, Kai Huang, Xiuyun Wang, Jiayou Chu, Xinyu Huang

Faculty Publications

Pathogen-driven balancing selection determines the richness of human leukocyte antigen (HLA) alleles. Changes in the pathogen spectrum may cause corresponding changes in HLA loci. Approximately 700 years ago, a Mongolian population moved from the north of China to the Yunnan region in the south of China. The pathogen spectrum in the south of China differs from that in the north. In this study, changes in the HLA genes in the Yunnan Mongolian population, as well as the underlying mechanism, were investigated. A sequence-based typing method (SBT) was used to genotype HLA-DRB1 in 470 individuals from two Mongolian populations and another …

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Cannabinoid-Mediated Epigenetic Regulation Of Immune Functions, Jessica Margaret Sido May 2015

Cannabinoid-Mediated Epigenetic Regulation Of Immune Functions, Jessica Margaret Sido

Theses and Dissertations

The cannabinoid system consisting of exogenous and endogenous ligands as well as dedicated receptors has been proposed to play a regulatory role in immune functions. The exogenous cannabinoid Δ9-tetrahydrocannabinol (THC), one of the most widely studied marijuana derivatives, has been associated with multiple anti-inflammatory properties over the years. The majority of THC research has centered on the shift from Th1 to Th2 responses however, the complexity of inflammation has since increased. Recent studies have revealed that epigenome, Th cell subsets, and immunoregulatory cell induction, are all known to impact inflammation. In the current research, we have attempted to look holistically …

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Understanding Phylogenies: Constructing And Interpreting Phylogenetic Trees, Joseph L. Staton Apr 2015

Understanding Phylogenies: Constructing And Interpreting Phylogenetic Trees, Joseph L. Staton

Journal of the South Carolina Academy of Science

Interpretation of phylogenetic trees is fundamental in understanding the relationships between organisms, their traits or characteristics, their ecology and even their genomic and developmental biology. As trees appear more often in basic texts, many students, and even their teachers, clearly understand little of how they are constructed and even less about what can be inferred from them about the history of the representatives analyzed. Not only are these trees a source of confusion on what they do tell us, often non-specialists infer things wrongly or, worse, others misuse them in an attempt to negate the validity of evolutionary theory. In …

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The Rise Of Carbon Nanoscience In South Carolina, Apparao M. Rao Apr 2015

The Rise Of Carbon Nanoscience In South Carolina, Apparao M. Rao

Journal of the South Carolina Academy of Science

No abstract provided.

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Scientific Contributions Of The Children’S Physical Activity Research Group, Russell R. Pate, Erica Y. Lau, Jennifer I. Flynn, Samantha M. Mcdonald, Morgan N. Clennin, Michaela A. Schenkelberg Apr 2015

Scientific Contributions Of The Children’S Physical Activity Research Group, Russell R. Pate, Erica Y. Lau, Jennifer I. Flynn, Samantha M. Mcdonald, Morgan N. Clennin, Michaela A. Schenkelberg

Journal of the South Carolina Academy of Science

No abstract provided.

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Characterization Of Stard4 And Stard6 Proteins In Human Ovarian Tissue And Human Granulosa Cells And Cloning Of Human Stard4 Transcripts, Aisha Shaaban Jan 2015

Characterization Of Stard4 And Stard6 Proteins In Human Ovarian Tissue And Human Granulosa Cells And Cloning Of Human Stard4 Transcripts, Aisha Shaaban

Theses and Dissertations

Progesterone is essential hormone for pregnancy, which is produced by the human corpus luteum in early pregnancy until the placenta assumes this function. Transport of the cholesterol from the outer to the inner mitochondrial membrane is the rate limiting step for the de novo synthesis of pregnenolone (the precursor to progesterone), a process mediated by STARD1. STARD1 contains a C-terminal lipid binding domain which binds cholesterol and an N-terminal domain targeting STARD1 to the mitochondrial membrane. Unlike STARD1, STARD4 and STARD6 proteins lack a mitochondrial targeting sequence; however, they can bind cholesterol and increase steroidogenesis in model systems. In this …

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Goal Achievement In Young Adults With Asperger Syndrome And High Functioning Autism, Melissa Racobaldo Jan 2015

Goal Achievement In Young Adults With Asperger Syndrome And High Functioning Autism, Melissa Racobaldo

Theses and Dissertations

Purpose: This study aimed to evaluate perspectives of young adults with Asperger syndrome (AS) and High Functioning Autism (HFA) regarding supports and services, future goals, and confidence in their success. The goal of this study was to identify valuable supports and areas in which this support was lacking. Identifying areas of support for young adults with AS/HFA transitioning into adulthood aids in providing consistent services for successful goal achievement. The study has value among genetic counselors as the discovery of genetic etiologies of autism has led to referral of families with ASD to the genetics clinic. Methods: Young adults with …

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