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Full-Text Articles in Medicine and Health Sciences
Comprehensive Comparison Of Clinicoradiological, Laboratory, And Prognostic Factors Of Community-Acquired Pneumonia In Diabetic And Nondiabetic Hospitalized Patients, Seyyed Hamid Hashemi, Fatemeh Saki, Shiva Borzouei, Rashed Bawand, Alireza Soltanian
Comprehensive Comparison Of Clinicoradiological, Laboratory, And Prognostic Factors Of Community-Acquired Pneumonia In Diabetic And Nondiabetic Hospitalized Patients, Seyyed Hamid Hashemi, Fatemeh Saki, Shiva Borzouei, Rashed Bawand, Alireza Soltanian
Turkish Journal of Medical Sciences
Background/aim: Community-acquired pneumonia (CAP) is one of the leading infectious causes of mortality, and diabetes mellitus is a globally prevalent disease. Consequently, the cooccurrence of these two disorders can be common and create challenging medical conditions. Therefore, it was aimed to compare the various aspects of CAP in diabetic and nondiabetic patients, in order to have a comprehensive and comparative picture of the differences. Materials and methods: In this cross-sectional study, CAP patients with and without diabetes were assessed for clinicoradiological signs, laboratory features, disease severity, and pneumonia outcomes. Results: Analyzed herein were 172 CAP patients (77 had diabetes and …
Clinical And Imaging Findings Of Patients Diagnosed With Adenovirus-Positivepneumonia During 2015-2019 In Shanghai, China, Chunrong Huang, Dong Wei, Yahui Liu, Guo Chao Shi
Clinical And Imaging Findings Of Patients Diagnosed With Adenovirus-Positivepneumonia During 2015-2019 In Shanghai, China, Chunrong Huang, Dong Wei, Yahui Liu, Guo Chao Shi
Turkish Journal of Medical Sciences
Background/aim: This study was to describe the clinical characteristics, chest CT image findings, and potential role of T cells immunity in adenovirus positive pneumonia. Materials/methods: In this retrospective study, medical records of 53 adult Adv+ patients who were admitted to the Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, from May 2015 to August 2019 were included. The presence of adenovirus and other respiratory viruses was detected using polymerase chain reaction of throat swabs samples. Clinical features and chest computed tomography (CT) findings were compared between patients with Adv+ pneumonia and Adv+ non-pneumonia. Results: The top 3 most commonly …
Galectin-3: Can It Be A Diagnostic Tool For Pneumonia In Covid-19 Patients?, Emi̇ne Kartal Baykan, Engi̇n Şebi̇n, Ömer Karaşahi̇n, Ahmed Rami̇z Baykan, Serkan Cerrah, Hasan Göğebakan, Can Sevi̇nç, Mustafa Kahraman, Yasemi̇n Coşkun Yavuz
Galectin-3: Can It Be A Diagnostic Tool For Pneumonia In Covid-19 Patients?, Emi̇ne Kartal Baykan, Engi̇n Şebi̇n, Ömer Karaşahi̇n, Ahmed Rami̇z Baykan, Serkan Cerrah, Hasan Göğebakan, Can Sevi̇nç, Mustafa Kahraman, Yasemi̇n Coşkun Yavuz
Turkish Journal of Medical Sciences
Background/aim: Biochemical markers are needed to show lung involvement in COVID-19 disease. Galectin-3 is known to play a key role in the inflammation and fibrosis process. We aimed to evaluate the predictive role of galectin-3 levels for pneumonia in patients with COVID-19. Materials and methods: Total of 176 patients with COVID-19, confirmed with reverse transcriptase polymerase chain reaction, admitted to the Erzurum Regional Training and Research Hospital was analyzed. The study was designed as a cross sectional. The baseline data of laboratory examinations, including galectin-3 were collected at the time of diagnosis. CT images evaluated by a single radiologist according …
Can Thrombocytosis Or Thrombocytopenia Predict Complicated Clinical Course And30-Days Mortality In Patients With Pneumonia?, Razi̇ye Si̇nem Misirlioğlu, Ersi̇n Aksay, Emre Şanci, Kemal Can Tertemi̇z
Can Thrombocytosis Or Thrombocytopenia Predict Complicated Clinical Course And30-Days Mortality In Patients With Pneumonia?, Razi̇ye Si̇nem Misirlioğlu, Ersi̇n Aksay, Emre Şanci, Kemal Can Tertemi̇z
Turkish Journal of Medical Sciences
Background/aim: While several different scoring systems aim to determine the clinical outcomes for patients with pneumonia, there is limited emphasis on the platelet count. This study investigated the relationships between thrombocyte count and 30-day mortality and complicated clinical course of patients with pneumonia. Materials and methods: This prospective cross-sectional study enrolled patients over 18 years old with a diagnosis of pneumonia in the emergency department for six months. The primary outcome was to establish the relationship between platelet count, mortality, complicated clinical course, and initial vital parameters on admission. The secondary outcome was comparing the platelet count with mortality and …
Hydroxychloroquine Plus Azithromycin And Early Hospital Admission Are Beneficial Incovid-19 Patients: Turkish Experience With Real-Life Data, Eli̇f Tanriverdi̇, Mustafa Çörtük, Bi̇nnaz Zeynep Yildirim, Efsun Gonca Uğur Chousein, Demet Turan, Hali̇t Çinarka, Mehmet Aki̇f Özgül, Erdoğan Çeti̇nkaya
Hydroxychloroquine Plus Azithromycin And Early Hospital Admission Are Beneficial Incovid-19 Patients: Turkish Experience With Real-Life Data, Eli̇f Tanriverdi̇, Mustafa Çörtük, Bi̇nnaz Zeynep Yildirim, Efsun Gonca Uğur Chousein, Demet Turan, Hali̇t Çinarka, Mehmet Aki̇f Özgül, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: New treatment regimens for COVID-19, which has threatened the world recently, continue to be investigated. Although some of the treatments are promising, it is thought to be early to state that there is definitive treatment. Experiences and treatment protocol studies from treatment centers are still important. The aim of this study is to evaluate factors affecting the treatment process of the first cases followed in our clinic. Materials and methods: The consecutive hospitalized patients with COVID-19 pneumonia were analyzed in this retrospective and cross-sectional study. Data were recorded from the electronic and written files of patients. Results: Eighty-three patients …
Evaluation Of The Chest Computed Tomography And Hemogram Data In Patients Withcovid-19: The Importance Of Thymus, Vefa Çakmak, Atakan Yilmaz, Tuğba Sari, Pinar Çakmak, Mert Özen, Duygu Herek, Alten Oskay
Evaluation Of The Chest Computed Tomography And Hemogram Data In Patients Withcovid-19: The Importance Of Thymus, Vefa Çakmak, Atakan Yilmaz, Tuğba Sari, Pinar Çakmak, Mert Özen, Duygu Herek, Alten Oskay
Turkish Journal of Medical Sciences
Background/aim: To investigate the relationship between imaging findings and peripheral blood cell counts of COVID-19 patients and the degree of thymus fat involution of these patients. Materials and methods: Computed tomography (CT) images of 87 patients with COVID-19 positive through RT-PCR testing were evaluated retrospectively by two radiologists. Ground glass densities and other signs of viral pneumonia were recorded, lung involvement was scored quantitatively. The patients thymus fat involution was graded on CT. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratios (PLR), lymphocyte and platelet counts were calculated. Imaging findings and degrees of thymus fat involution were compared with laboratory data. Results: Quantitative …
The Comparison Of Favipiravir And Lopinavir/Ritonavir Combination In Covid-19treatment, Hali̇t Çinarka, Gülşah Günlüoğlu, Mustafa Çörtük, Si̇bel Yurt, Murat Kiyik, Ayşe Fi̇li̇z Koşar, Eli̇f Tanriverdi̇, Meli̇h Akay Arslan, Kürşad Nuri̇ Baydi̇li̇, Aysu Si̇nem Koç, Sedat Altin, Erdoğan Çeti̇nkaya
The Comparison Of Favipiravir And Lopinavir/Ritonavir Combination In Covid-19treatment, Hali̇t Çinarka, Gülşah Günlüoğlu, Mustafa Çörtük, Si̇bel Yurt, Murat Kiyik, Ayşe Fi̇li̇z Koşar, Eli̇f Tanriverdi̇, Meli̇h Akay Arslan, Kürşad Nuri̇ Baydi̇li̇, Aysu Si̇nem Koç, Sedat Altin, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: SARS-CoV-2, a ribonucleic acid coronavirus, rapidly spread worldwide within a short timeframe. Although different antiviral, antiinflammatory, and immunomodulatory drugs are used, current evidence is insufficient as to which drug is more efficient. Our study compared favipiravir and lopinavir/ritonavir (LPV/RTV) therapies in inpatient care for coronavirus disease 2019 (COVID-19) pneumonia. Materials and methods: Demographic data, test results, treatments, and latest status of patients receiving inpatient COVID-19 pneumonia therapy were recorded. The initial favipiravir and LPV/RTV receiving groups were compared regarding the need for intensive care units (ICU) and mortality. Logistic regression analysis was performed by including variables showing significant differences …
Chest Ct Features Of The Novel Coronavirus Disease (Covid-19), Furkan Ufuk, Recep Savaş
Chest Ct Features Of The Novel Coronavirus Disease (Covid-19), Furkan Ufuk, Recep Savaş
Turkish Journal of Medical Sciences
A new type of coronavirus (2019-nCoV) is rapidly spreading worldwide and causes pneumonia, respiratory distress, thromboembolic events, and death. Chest computed tomography (CT) plays an essential role in the diagnosis of viral pneumonia, monitoring disease progression, determination of disease severity, and evaluating therapeutic efficacy. Chest CT can show important clues of 2019-nCoV disease (also known as COVID-19) in patients with an appropriate clinic. Prompt diagnosis of COVID-19 is essential to prevent disease transmission and provides close clinical observation of patients with clinically severe disease. Therefore, radiologists and clinicians should be familiar with the CT imaging findings of COVID-19 pneumonia. Herein, …
The Factors Predicting Pneumonia In Covid-19 Patients: Preliminary Results From Auniversity Hospital In Turkey, Hasan Selçuk Özger, Pinar Aysert Yildiz, Ümmügülsüm Gaygisiz, Asi̇ye Uğraş Di̇kmen, Zehra Demi̇rbaş Gülmez, Mehmet Yildiz, Esi̇n Şenol, Kenan Hizel, Özlem Güzel Tunçcan, Kayhan Çağlar, Gülendam Bozdayi, Nurdan Köktürk, Tansu Ulukavak Çi̇ftçi̇, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu
The Factors Predicting Pneumonia In Covid-19 Patients: Preliminary Results From Auniversity Hospital In Turkey, Hasan Selçuk Özger, Pinar Aysert Yildiz, Ümmügülsüm Gaygisiz, Asi̇ye Uğraş Di̇kmen, Zehra Demi̇rbaş Gülmez, Mehmet Yildiz, Esi̇n Şenol, Kenan Hizel, Özlem Güzel Tunçcan, Kayhan Çağlar, Gülendam Bozdayi, Nurdan Köktürk, Tansu Ulukavak Çi̇ftçi̇, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu
Turkish Journal of Medical Sciences
Background/aim: Pneumonia is the most serious clinical presentation of COVID-19. This study aimed to determine the demographic, clinical, and laboratory findings that can properly predict COVID-19 pneumonia. Materials and methods: This study was conducted in the Gazi University hospital. All hospitalized patients with confirmed and suspected SARS-CoV-2 infection between 16 March 2020 and 30 April 2020 were analyzed retrospectively. COVID-19 patients were separated into two groups, pneumonia and nonpneumonia, and then compared to determine predicting factors for COVID-19 pneumonia. Variables that had a P-value of less than 0.20 and were not correlated with each other were included in the logistic …
Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay, Tevfi̇k Özlü, Aydin Yilmaz
Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay, Tevfi̇k Özlü, Aydin Yilmaz
Turkish Journal of Medical Sciences
COVID-19 pneumonia has high mortality rates. The symptoms are undiagnostic, the results of viral nucleic acid detection method (PCR) can delay, so that chest computerized tomography is often key diagnostic test in patients with possible COVID-19 pneumonia. In this review, we discussed the main radiological findings of this infection.
Investigation Of Phikz Phage Therapy Against Pseudomonas Aeruginosa In Mousepneumonia Model, Kübra Can, Uğur Aksu, Osman Şadi̇ Yenen
Investigation Of Phikz Phage Therapy Against Pseudomonas Aeruginosa In Mousepneumonia Model, Kübra Can, Uğur Aksu, Osman Şadi̇ Yenen
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined. Materials and methods: The systemic, lung-specific, and kidney-specific inflammation levels and the bacterial load in lung tissue and biochemical parameters were investigated after PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the P. aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined by measuring plasma levels of …
Antibiotic Treatment Outcomes In Community-Acquired Pneumonia, Aykut Çi̇lli̇, Abdullah Sayiner, Burcu Çelenk, Ayşin Şakar Coşkun, Oğuz Kilinç, Armağan Hazar, Anil Aktaş Samur, Sezai̇ Taşbakan, Grant W. Waterer, Yavuz Havlucu, Öznur Kiliç, Fatma Tokgöz, Uğur Bi̇lge
Antibiotic Treatment Outcomes In Community-Acquired Pneumonia, Aykut Çi̇lli̇, Abdullah Sayiner, Burcu Çelenk, Ayşin Şakar Coşkun, Oğuz Kilinç, Armağan Hazar, Anil Aktaş Samur, Sezai̇ Taşbakan, Grant W. Waterer, Yavuz Havlucu, Öznur Kiliç, Fatma Tokgöz, Uğur Bi̇lge
Turkish Journal of Medical Sciences
Background/aim: The optimal empiric antibiotic regimen for patients with community-acquired pneumonia (CAP) remains unclear. This study aimed to evaluate the clinical cure rate, mortality, and length of stay among patients hospitalized with communityacquired pneumonia in nonintensive care unit (ICU) wards and treated with a ß-lactam, ß-lactam and macrolide combination, or a fluoroquinolone. Materials and methods: This prospective cohort study was performed using standardized web-based database sheets from January 2009 to September 2013 in nine tertiary care hospitals in Turkey. Results: Six hundred and twenty-one consecutive patients were enrolled. A pathogen was identified in 78 (12.6%) patients. The most frequently isolated …
Complications Of Tracheobronchial Foreign Bodies, Bayram Altuntaş, Yener Aydin, Ati̇la Eroğlu
Complications Of Tracheobronchial Foreign Bodies, Bayram Altuntaş, Yener Aydin, Ati̇la Eroğlu
Turkish Journal of Medical Sciences
Background/aim: Tracheobronchial foreign bodies may cause several complications in the respiratory system. We aimed to present the complications of tracheobronchial foreign bodies. Materials and methods: Between January 1990 and March 2015, 813 patients with suspected tracheobronchial foreign body aspiration were hospitalized in our department. Patients with complications related to foreign bodies in airways were included in this study. We retrospectively evaluated the records of patients according to symptoms, foreign body type, localizations, and complications. Results: A foreign body was found in 701 of 813 patients (86.2%). Complications related to foreign bodies settled in airways were seen in 96 patients (13.7%). …
Serum Procalcitonin And C-Reactive Protein Kinetics As Indicators Of Treatmentoutcome In Hospitalized Patients With Community-Acquired Pneumonia, Mehmet Sezai̇ Taşbakan, Canan Gündüz, Abdullah Sayiner, Aykut Çi̇lli̇, Burcu Çelenk Karaboğa, Ayşin Şakar Coşkun, Feri̇de Durmaz Yaman, Oğuz Kilinç, Öznur Kiliç Soylar
Serum Procalcitonin And C-Reactive Protein Kinetics As Indicators Of Treatmentoutcome In Hospitalized Patients With Community-Acquired Pneumonia, Mehmet Sezai̇ Taşbakan, Canan Gündüz, Abdullah Sayiner, Aykut Çi̇lli̇, Burcu Çelenk Karaboğa, Ayşin Şakar Coşkun, Feri̇de Durmaz Yaman, Oğuz Kilinç, Öznur Kiliç Soylar
Turkish Journal of Medical Sciences
Background/aim: There has been growing interest in the use of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with community-acquired pneumonia (CAP). The aim of this study was to investigate whether an assessment of fever, leukocyte count, and serum CRP and PCT levels on admission and during follow-up (day 3) provides any information about the clinical outcome in hospitalized patients with CAP. Materials and methods: Patients with a diagnosis of CAP who were admitted to and followed at four university hospitals were evaluated retrospectively using the Turkish Thoracic Society Pneumonia Database. Results: A total of 103 hospitalized CAP patients …
Clinical Characteristics Of 75 Pandemic H1n1 Influenza Patientsfrom Turkey; Risk Factors For Fatality, Hati̇ce Kiliç, Asi̇ye Kanbay, Ayşegül Karalezli̇, Hati̇ce Canan Hasanoğlu, Can Ateş
Clinical Characteristics Of 75 Pandemic H1n1 Influenza Patientsfrom Turkey; Risk Factors For Fatality, Hati̇ce Kiliç, Asi̇ye Kanbay, Ayşegül Karalezli̇, Hati̇ce Canan Hasanoğlu, Can Ateş
Turkish Journal of Medical Sciences
Background/aim: The 2009 influenza A (H1N1) pandemic caused mild to severe illnesses and led to death in some cases. In this study, we aimed to evaluate the relationship between the serum D-dimer levels, CURB-65 scores, and the severity of pneumonia among patients with H1N1 infections. Materials and methods: Sixty-eight patients who had probable H1N1 infections were evaluated by clinical, radiological, and laboratory methods. The H1N1 strain was specified by reverse transcription-polymerase chain reaction. Of 55 patients diagnosed with pneumonia, 18 exhibited H1N1 positivity and 37 patients did not. Results: CURB-65 scores of pneumonia patients with H1N1 (group 1) were higher …
Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk
Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk
Turkish Journal of Medical Sciences
Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP). Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre- and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography. Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and …
Epidemiology, Clinical Features, And Laboratory Detection Of Mycoplasma Pneumoniae Infection In East Azerbaijan, Iran, Reza Ghotaslou, Simin Sharifi, Mohammad Taghi Akhi, Mohammad Hossein Soroush
Epidemiology, Clinical Features, And Laboratory Detection Of Mycoplasma Pneumoniae Infection In East Azerbaijan, Iran, Reza Ghotaslou, Simin Sharifi, Mohammad Taghi Akhi, Mohammad Hossein Soroush
Turkish Journal of Medical Sciences
Mycoplasma pneumoniae is involved in the etiology of many respiratory tract infections. This prospective study describes the epidemiology and clinical properties of M. pneumoniae infections in hospitals of the Tabriz University of Medical Sciences. Materials and methods: From May 2009 to November 2010, 200 patients with respiratory tract infections were enrolled into this study. Due to antibiotic use 51 patients were excluded. M. pneumoniae from respiratory infections was detected by culture, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR) assays. Results: M. pneumoniae infection was detected in 9 (6.15%), 8 (5.3%), and 3 (2.01%) of patients by PCR, ELISA, …
Cut-Off Value Of D-Dimer In Pulmonary Thromboembolism And Pneumonia, Ayşegül Karalezli̇, H. Canan Hasanoğlu, Selda Kaya, Eli̇f Babaoğlu, Z. Ci̇bali̇ Açikgöz, Asi̇ye Kanbay, Derya Öztuna
Cut-Off Value Of D-Dimer In Pulmonary Thromboembolism And Pneumonia, Ayşegül Karalezli̇, H. Canan Hasanoğlu, Selda Kaya, Eli̇f Babaoğlu, Z. Ci̇bali̇ Açikgöz, Asi̇ye Kanbay, Derya Öztuna
Turkish Journal of Medical Sciences
Aim: The differential diagnosis of pulmonary thromboembolism (PTE) and pneumonia remains difficult in emergency rooms. High D-dimer levels in the pneumonia may be misdiagnosed as PTE on the basis of similar clinical, radiological, and laboratory findings. Since D-dimer elevation may also be seen in pneumonia cases, the comparison of D-dimer values in patients diagnosed as pneumonia and PTE, in order to determine a cut-off value between the 2 diseases, was aimed in this study. Materials and methods: Patients in the community acquired pneumonia (CAP) group were classified according to the American Thoracic Society (ATS) 2001 criteria. Groups III and IV …