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Articles 1 - 30 of 282
Full-Text Articles in Medicine and Health Sciences
The Effectiveness And Clinical Outcomes Of The Minerva Cervical Thoracicjacket In Patients With Type Ii Odontoid Fractures, Sai̇t Öztürk, Fati̇h Serhat Erol, Beki̇r Akgün, Meti̇n Kaplan
The Effectiveness And Clinical Outcomes Of The Minerva Cervical Thoracicjacket In Patients With Type Ii Odontoid Fractures, Sai̇t Öztürk, Fati̇h Serhat Erol, Beki̇r Akgün, Meti̇n Kaplan
Turkish Journal of Medical Sciences
Background/aim: The objective of this study was to carry out a detailed analysis and assess the outcomes for the Minerva cervical thoracic jacket (CTJ) in patients with type II odontoid fractures who could not be surgically treated. Materials and methods: Twenty-six patients for whom the Minerva CTJ was used rather than surgery for different reasons were included in the study. All patients were fitted with the Minerva CTJ within the first 24 h following diagnosis. The patients were followed 4 weeks after hospital discharge and then at 2-week intervals. Results were considered significant at P < 0.05 and a 95% confidence interval was calculated. Results: Of the 26 patients, 17 were male and 9 were female. The mean age was 49.03 years old (range: 16?86 years old). Fusion occurred in 25 of the 26 patients (P = 0.004), and the mean time to fusion was 6.8 weeks (P = 0.002). The mean length of hospital stay was 4 days and the mean follow-up period was 7.3 weeks. None of the patients had any complications due to the Minerva CTJ and the mortality rate was 0%. Conclusions: The Minerva CTJ application was a safe and cheap technique in the management of type II odontoid fractures. It had a high fusion rate and no complications.
The Knowledge And High Seroprevalence Of Hepatitis A In A High-Risk Group(Agricultural Reproductive-Aged Women) In The Southeastern Region Of Turkey, Nebi̇ye Yentür Doni̇, Zeynep Şi̇mşek, Gülcan Gürses, Fadi̇le Yildiz Zeyrek, Muhsi̇n Akbaba
The Knowledge And High Seroprevalence Of Hepatitis A In A High-Risk Group(Agricultural Reproductive-Aged Women) In The Southeastern Region Of Turkey, Nebi̇ye Yentür Doni̇, Zeynep Şi̇mşek, Gülcan Gürses, Fadi̇le Yildiz Zeyrek, Muhsi̇n Akbaba
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the seroprevalence of antihepatitis A virus (HAV), risk factors, and the knowledge of female farm workers living in the Southeastern Anatolia Region (SAR) of Turkey. Materials and methods: This representative cross-sectional survey was conducted between January and April of 2013 in the SAR. A total of 705 reproductive-aged women were randomly selected by clustering method using Epi Info software. The sera were analyzed for anti-HAV antibodies using ELISA. Sociodemographic information and the knowledge of female farm workers regarding hepatitis A were collected using a questionnaire. Results: Of the female farm workers, …
Endovascular Embolization In The Management Of Traumatic Andpostoperative Abdominopelvic Bleeding: A Single-Center Experience, Di̇lek Sağlam, Hasan Di̇nç, Abdulkadi̇r Gündüz, Ayşegül Cansu, Mehmet Hali̇l Öztürk
Endovascular Embolization In The Management Of Traumatic Andpostoperative Abdominopelvic Bleeding: A Single-Center Experience, Di̇lek Sağlam, Hasan Di̇nç, Abdulkadi̇r Gündüz, Ayşegül Cansu, Mehmet Hali̇l Öztürk
Turkish Journal of Medical Sciences
Background/aim: Endovascular embolization is widely used instead of surgery in the treatment of traumatic and postoperative abdominopelvic bleeding. The objective of this study is to evaluate the efficiency of computed tomography in the determination of active bleeding and the efficiency of endovascular embolization in traumatic and postoperative abdominopelvic bleeding. Materials and methods: Thirty-one patients admitted to our hospital with traumatic and postoperative abdominopelvic bleeding between January 2006 and September 2012 and treated with endovascular embolization were retrospectively enrolled in the study. In 15 hemodynamically stable patients, abdominal computed tomography was performed to detect the presence and/or localization of the hemorrhage. …
A Nationwide Evaluation Of Off-Label Drug Utilization In Turkey, Emi̇ne Nur Özdamar, Ahmet Akici, Ali̇ Alkan, Banu Bayar, Hakki Gürsöz
A Nationwide Evaluation Of Off-Label Drug Utilization In Turkey, Emi̇ne Nur Özdamar, Ahmet Akici, Ali̇ Alkan, Banu Bayar, Hakki Gürsöz
Turkish Journal of Medical Sciences
Background/aim: Off-label drug use (OLDU) is under the control of the Turkish Medicines and Medical Devices Agency (TMMDA) in Turkey. It was aimed to investigate demographic and medical features of patients with OLDU applications in Turkey. Materials and methods: A total of 4426 electronic OLDU application records of the TMMDA were evaluated retrospectively. Information regarding patients? demographic characteristics, diagnoses, requested drugs, institutions, and specialties of the physicians were evaluated. Results: OLDU applications were mostly made by rheumatologists (21.5%) and 95.2% of them were approved by the TMMDA. The mean age of the patients was 35 years and 54.4% of them …
Prevention Of Propofol Injection-Related Pain Using Pretreatment Transcutaneous Electrical Acupoint Stimulation, Luping Huang, Yuanyuan Pan, Sijia Chen, Minyuan Zhang, Xiuxiu Zhuang, Shenhui Jin, Junlu Wang, Qinxue Dai, Yunchang Mo
Prevention Of Propofol Injection-Related Pain Using Pretreatment Transcutaneous Electrical Acupoint Stimulation, Luping Huang, Yuanyuan Pan, Sijia Chen, Minyuan Zhang, Xiuxiu Zhuang, Shenhui Jin, Junlu Wang, Qinxue Dai, Yunchang Mo
Turkish Journal of Medical Sciences
Background/aim: This study aimed to study the effect of pretreatment transcutaneous electrical acupoint stimulation (TEAS) in preventing propofol injection-related pain. Materials and methods: A total of 360 patients who were to undergo elective hysteroscopy surgery were randomly divided into the following three groups of 120 patients each: control (Group C), sham TEAS (Group F), and TEAS (Group T). Patients in Group C did not undergo any treatment before surgery; 30 min before the induction of anesthesia, patients in Groups F and T underwent electrical stimulation of the bilateral LI4-PC6 acupoint. Patients in Group F were subjected to 'feeling flow', while …
Comparison Of Microscopy, Elisa, And Real-Time Pcr For Detectionof Giardia Intestinalis In Human Stool Specimens, Yunus Emre Beyhan, Zeynep Taş Cengi̇z
Comparison Of Microscopy, Elisa, And Real-Time Pcr For Detectionof Giardia Intestinalis In Human Stool Specimens, Yunus Emre Beyhan, Zeynep Taş Cengi̇z
Turkish Journal of Medical Sciences
Background/aim: This study included patients who had digestive system complaints between August 2015 and October 2015. The research was designed to compare conventional microscopy with an antigen detection ELISA kit and the TaqMan-based real-time PCR (RT-PCR) technique for detection of Giardia intestinalis in human stool specimens. Materials and methods: Samples were concentrated by formalin-ether sedimentation technique and microscopic examinations were carried out on wet mount slides. A commercially available ELISA kit (Giardia CELISA, Cellabs, Brookvale, Australia) was used for immunoassay. DNA was extracted from fecal samples of about 200 mg using the QIAamp Fast DNA Stool Mini Kit (QIAGEN, Hilden, …
Common Spink-1 Genetic Mutations Do Not Predispose To Crohn`S Disease, Nevi̇n Oruç, Necla Osmanoğlu, Çağdaş Aktan, Afi̇g Berdeli̇, Ahmet Ömer Özütemi̇z
Common Spink-1 Genetic Mutations Do Not Predispose To Crohn`S Disease, Nevi̇n Oruç, Necla Osmanoğlu, Çağdaş Aktan, Afi̇g Berdeli̇, Ahmet Ömer Özütemi̇z
Turkish Journal of Medical Sciences
No abstract provided.
Intravitreal Prn Ranibizumab Treatment For Macular Edemadue To Branch Retinal Vein Occlusion, Hasan Basri̇ Çakmak, Mücella Arikan Yorgun, Yasi̇n Toklu, Melek Mutlu
Intravitreal Prn Ranibizumab Treatment For Macular Edemadue To Branch Retinal Vein Occlusion, Hasan Basri̇ Çakmak, Mücella Arikan Yorgun, Yasi̇n Toklu, Melek Mutlu
Turkish Journal of Medical Sciences
Background/aim: To evaluate the effect of intravitreal pro re nata (PRN) ranibizumab treatment from the start on the best-corrected visual acuity (BCVA) and the central retinal thickness (CRT) in macular edema (ME) due to branch retinal vein occlusion (BRVO). Materials and methods: Patients with ME secondary to BRVO, who were treated on a PRN basis after a single intravitreal ranibizumab injection, were retrospectively evaluated. The main outcome measures were changes in BCVA and CRT as measured by optical coherence tomography. Results: The number of injections over 6 months was 2.43 ± 1.16. The mean BCVA of the patients was 0.84 …
Groin And Thigh Reconstructions With Pedicled Rectus Abdominis Myocutaneous Flaps, Hakan Uzun, Ozan Bi̇ti̇k, Yahya Baltu, Mehmet Dadaci, Aycan Uğur Kayikçioğlu
Groin And Thigh Reconstructions With Pedicled Rectus Abdominis Myocutaneous Flaps, Hakan Uzun, Ozan Bi̇ti̇k, Yahya Baltu, Mehmet Dadaci, Aycan Uğur Kayikçioğlu
Turkish Journal of Medical Sciences
Background/aim: Resection of tumors from the groin and thigh regions with safe margins often results in significant soft tissue defects, which preclude primary closure. This study presents a series of rectus abdominis myocutaneous flaps for irradiated thigh and groin wounds with the purpose of evaluating the efficacy and outcomes of these flaps in this population. Materials and methods: From 2008 to 2015, all patients who underwent resection of thigh or groin region tumors and reconstruction with an inferiorly based rectus abdominis myocutaneous flap were retrospectively identified. Medical records of the patients were reviewed. Results: A total of 27 patients, aged …
Effects Of A Closed System Suction Connector On Airwayresistance In Ventilated Neonates, Sezi̇n Ünal, Nuri̇ye Ebru Ergenekon, Ebru Kazanci, Selma Aktaş, Feri̇t Kulali, İbrahi̇m Murat Hirfanoğlu, Canan Türkyilmaz, Yildiz Atalay
Effects Of A Closed System Suction Connector On Airwayresistance In Ventilated Neonates, Sezi̇n Ünal, Nuri̇ye Ebru Ergenekon, Ebru Kazanci, Selma Aktaş, Feri̇t Kulali, İbrahi̇m Murat Hirfanoğlu, Canan Türkyilmaz, Yildiz Atalay
Turkish Journal of Medical Sciences
Background/aim: Increased airway resistance reduces the effectiveness of ventilation treatment. Endotracheal tubes (ETTs) and connectors contribute to resistance. However, the effect of a closed system suction (CSS) connector is not well known. We compared the in vivo resistance occurring with a CSS connector with that of the standard connector. Materials and methods: This prospective study was conducted at Gazi University Hospital's neonatal intensive care unit. Intubated neonates were studied for two cycles; each cycle contained two periods of ETT + connector pairs (15 min/period) as follows: cycle 1 [A: long ETT + standard connector; B: long ETT + CSS connector] …
Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul
Is There Any Difference In Tetanus Igg Levels Of Diabetic Patientswith Respect To The Presence Of Foot Ulcers?, Fati̇h Teki̇n, Mehmet Sürmeli̇, Zeynep Çi̇zmeci̇, Özlem Teki̇n, Ergi̇n Işik, Ömer Faruk Taner, Derun Taner Ertuğrul
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to reveal the tetanus immunization status of diabetic patients and to determine whether diabetic patients with foot ulcers have different TIG levels. Materials and methods: A cross-sectional study was designed that included diabetic patients with foot ulcers (n = 30) and diabetic patients without ulcers (n = 30). The groups were compared for serum TIG levels along with total serum protein, albumin, C-reactive protein (CRP), and total immunoglobulin G (Ig G). Results: For diabetic patients without foot ulcers, 17 of 30 (56.6%) patients were found to have nonprotective TIG levels whereas for diabetic …
Sex-Related Differences In Copd Assessment Test Scores Of Copd Populationswith Or Without Significant Anxiety And/Or Depression, Yelda Varol, Ceyda Anar, Pinar Çi̇men, Mehmet Ünlü, Hüseyi̇n Hali̇lçolar, Sali̇h Zeki̇ Güçlü
Sex-Related Differences In Copd Assessment Test Scores Of Copd Populationswith Or Without Significant Anxiety And/Or Depression, Yelda Varol, Ceyda Anar, Pinar Çi̇men, Mehmet Ünlü, Hüseyi̇n Hali̇lçolar, Sali̇h Zeki̇ Güçlü
Turkish Journal of Medical Sciences
Background/aim: Sex-related differences have not been thoroughly explored in chronic obstructive pulmonary disease (COPD). We aimed to evaluate possible sex-related differences in COPD Assessment Test (CAT) scores of COPD patients with or without significant anxiety and/or depression. Materials and methods: Stable COPD patients were prospectively enrolled in the study between July 2013 and April 2014. Levels of anxiety, depression, dyspnea, and health-related quality of life parameters were assessed using specific questionnaires, including the CAT and others. Demographic and clinical data were recorded and physiological tests were performed. All the data were compared to determine any sex-related differences. Results: A total …
Fecal Carriage Of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli And Klebsiella Spp. In A Turkish Community, Derya Çakir Erdoğan, Füsun Cömert, Eli̇f Aktaş Sepetci̇, Fürüzan Köktürk, Canan Külah
Fecal Carriage Of Extended-Spectrum Beta-Lactamase-Producing Escherichia Coli And Klebsiella Spp. In A Turkish Community, Derya Çakir Erdoğan, Füsun Cömert, Eli̇f Aktaş Sepetci̇, Fürüzan Köktürk, Canan Külah
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the prevalence of fecal carriage of extended-spectrum beta-lactamase (ESBL)-producing bacteria, enzyme types, and risk factors affecting colonization. Materials and methods: A total of 576 stool samples from outpatients were examined between October 2012 and May 2013. Screening was done with selective EMB plates. ESBL were detected by double-disk synergy and confirmed agar strip gradient methods. Enzyme types were determined by PCR. Results: The prevalence of fecal carriage was found as 30% (173 of 576). Recent use of antibiotics, hospitalization and surgical operation, diabetes, crowded household populations, and old age were associated …
Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz
Significant Association Between Scgb1d4 Gene Polymorphisms And Susceptibility To Adenoid Hypertrophy In A Pediatric Population, Tali̇h Özdaş, Si̇bel Özdaş, Mehmet Ali̇ Babademez, Sami̇ Engi̇n Muz, Mahmut Huntürk Ati̇lla, Si̇bel Başti̇mur, Afi̇fe İzbirak, Kenan Kurt, Işilay Öz
Turkish Journal of Medical Sciences
Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of …
Attitudes And Behaviors Of Physicians In Dealing With Difficult Patientsand Relatives: A Cross-Sectional Study In Two Training And Research Hospitals, Kamuran Bahar Sandikci, Yusuf Üstü, Mert Muhi̇tti̇n Sandikci, Burcu Kayhan Teti̇k, Derya Işik, Mehmet Uğurlu
Attitudes And Behaviors Of Physicians In Dealing With Difficult Patientsand Relatives: A Cross-Sectional Study In Two Training And Research Hospitals, Kamuran Bahar Sandikci, Yusuf Üstü, Mert Muhi̇tti̇n Sandikci, Burcu Kayhan Teti̇k, Derya Işik, Mehmet Uğurlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to examine the reasons constituting the definition of 'difficult patient' and to evaluate attitudes and behaviors of physicians in coping with these patients and their relatives. Materials and methods: This cross-sectional study was conducted in May and June 2013 with 400 randomly selected physicians from different specialties working in two training and research hospitals in Ankara. A questionnaire was created by reviewing the relevant literature, by family medicine clinic, and delivered to the physicians following a pilot study. Results: In our study 92.8% of the physicians participating had experienced a negative contact with …
Radiation Therapy For Biliary Tract Tumors: The Joint Experience Of Three Centers, Mehmet Si̇nan Karabey, Eda Yi̇rmi̇beşoğlu Erkal, Ahmet Yolcu, Beki̇r Hakan Bakkal, Özlem Ay, Maksut Görkem Aksu, Emi̇ne Bi̇nnaz Sarper, Haldun Şükrü Erkal
Radiation Therapy For Biliary Tract Tumors: The Joint Experience Of Three Centers, Mehmet Si̇nan Karabey, Eda Yi̇rmi̇beşoğlu Erkal, Ahmet Yolcu, Beki̇r Hakan Bakkal, Özlem Ay, Maksut Görkem Aksu, Emi̇ne Bi̇nnaz Sarper, Haldun Şükrü Erkal
Turkish Journal of Medical Sciences
Background/aim: This study presents the joint experience of three centers in the treatment of patients with biliary tract tumors with radiation therapy (RT). Materials and methods: The records of 27 patients were retrospectively reviewed. All of the patients who had undergone surgical resection received postoperative adjuvant RT, whereas all of the patients who had not undergone a surgical resection received RT with palliative intent. Twenty patients with adequate performance status were treated with RT and chemotherapy, while the remaining seven patients were treated with RT alone. Results: Follow-up ranged from 1 to 44 months. Local control was not achieved in …
Wheezing, Asthma, And Atopy In Premature Infants At 2 Years Of Age, Sevi̇m Ünal, Ayşenur Kaya, Leyla Bi̇lgi̇n, Emi̇ne Di̇bek Misirlioğlu, Can Naci̇ Kocabaş
Wheezing, Asthma, And Atopy In Premature Infants At 2 Years Of Age, Sevi̇m Ünal, Ayşenur Kaya, Leyla Bi̇lgi̇n, Emi̇ne Di̇bek Misirlioğlu, Can Naci̇ Kocabaş
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate wheezing, bronchial asthma (BA), and atopy in premature infants at 2 years of age via a crosssectional study. Materials and methods: Premature infants at <37 weeks of gestational age (GA) were assessed for atopy by skin-prick test and serum immunoglobulin E level at 2 years of age. The family's and infant's histories of allergy, BA, atopy, and wheezing were obtained by questionnaire and from hospital records. Results: There were 98 infants, with mean birth weight (BW) 1517.4 ± 486.5 g and GA 30.8 ± 2.9 weeks. The frequencies of wheezing, asthma, and bronchopulmonary dysplasia (BPD) were 32.7%, 16.3%, and 14.3%, respectively. Skin-prick tests were positive for 11 subjects, with allergy to cereals for 7 infants, egg for 3, and peanut for 1. Wheezing was related to GA, BW, respiratory distress syndrome, mechanical ventilation, sepsis, asphyxia, smoking, antenatal steroid, BA, palivizumab prophylaxis, number of people in the household, and duration of hospitalization (P < 0.05). Wheezing was negatively correlated to GA. Family history of BA, smoking, and number of people in the household were linked to BA (P < 0.05). Conclusion: Wheezing was related to degree of premature birth, but BA was linked to BA in the family and smoking. Increased gestation should improve the infant's respiratory health up to 2 years of age.
Predictive Values Of Plasma Kl-6 In Bronchopulmonary Dysplasia In Preterm Infants, Di̇lek Di̇lli̇, Ahmet Özyazici, Arzu Dursun, Serdar Beken, Nurdan Di̇nlen Fettah, Aysegul Zenci̇roğlu, Nurullah Okumuş
Predictive Values Of Plasma Kl-6 In Bronchopulmonary Dysplasia In Preterm Infants, Di̇lek Di̇lli̇, Ahmet Özyazici, Arzu Dursun, Serdar Beken, Nurdan Di̇nlen Fettah, Aysegul Zenci̇roğlu, Nurullah Okumuş
Turkish Journal of Medical Sciences
Background/aim: It has been suggested that plasma KL-6 increases in premature infants with bronchopulmonary dysplasia (BPD). We aimed to evaluate the predictive values of KL-6 in BPD. Materials and methods: The study was performed in preterm neonates with birthweight ≤1500 g and gestational age ≤32 weeks. Plasma KL-6 levels were measured on postnatal days 1, 7, and 14. Results: BPD was identified in eight of the 28 study infants. On postnatal days 1 and 7, plasma KL-6 levels were similar in infants with BPD [on day 1: 8.9 (7.5-17.8) U/mL and on day 7: 16.8 (10.5-47.7) U/mL] and without BPD …
Evaluation Of Quality Of Life And Cost-Effectiveness Of Definitive Surgery And The Levonorgestrel Intrauterine System As Treatment Options For Heavy Menstrual Bleeding, Cevdet Adigüzel, Sevtap Seyfetti̇noğlu, Deni̇z Aka Satar, Sefa Arlier, Eda Eski̇mez, Fatma Kaya, Hakan Nazi̇k
Evaluation Of Quality Of Life And Cost-Effectiveness Of Definitive Surgery And The Levonorgestrel Intrauterine System As Treatment Options For Heavy Menstrual Bleeding, Cevdet Adigüzel, Sevtap Seyfetti̇noğlu, Deni̇z Aka Satar, Sefa Arlier, Eda Eski̇mez, Fatma Kaya, Hakan Nazi̇k
Turkish Journal of Medical Sciences
Background/aim: This study aimed to compare the levonorgestrel intrauterine system (LNG-IUS) with abdominal hysterectomy (TAH) and total laparoscopic hysterectomy (TLH) as first-line treatments for heavy menstrual bleeding (HMB). Materials and methods: Ninety-eight patients aged 20-55 years who complained of regular heavy menstrual bleeding were enrolled in the study. The TAH group included 29 patients, the LNG-IUS group included 34, and the TLH group included 35. These groups were compared in terms of quality of life and the cost-effectiveness of the selected methods. Quality of life was assessed using the 36-Item Short Form (SF-36), and cost-effectiveness was assessed according to the …
Vitamin E As A Novel Therapy In The Treatment Of Acute Aluminum Phosphide Poisoning, Zahra Halvaei, Hiva Tehrani, Kambiz Soltaninejad, Mohammad Abdollahi, Shahin Shadnia
Vitamin E As A Novel Therapy In The Treatment Of Acute Aluminum Phosphide Poisoning, Zahra Halvaei, Hiva Tehrani, Kambiz Soltaninejad, Mohammad Abdollahi, Shahin Shadnia
Turkish Journal of Medical Sciences
Background/aim: Aluminum phosphide (AlP) is commonly used as a fumigant in developing countries. Induction of oxidative stress is one of the most important mechanisms of its toxicity. In this regard, and considering that there is no specific antidote for its treatment, the aim of this study was to evaluate the effect of vitamin E in the treatment of acute AlP poisoning. Materials and methods: This was a clinical trial on acute AlP poisoned patients. All patients received supportive treatment. In addition, the treatment group received vitamin E (400 mg/BD/IM). Level of malondialdehyde (MDA) and total antioxidant capacity of plasma were …
Analysis Of Epidemiology And Risk Factors For Mortality In Ventilator-Associated Pneumonia Attacks In Intensive Care Unit Patients, Ayşe But, Meltem Arzu Yetki̇n, Di̇lek Kanyilmaz, Hali̇de Aslaner, Ali̇ye Baştuğ, Adalet Aypak, Pinar Öngürü, Esragül Akinci, Nevzat Mehmet Mutlu, Hurrem Bodur
Analysis Of Epidemiology And Risk Factors For Mortality In Ventilator-Associated Pneumonia Attacks In Intensive Care Unit Patients, Ayşe But, Meltem Arzu Yetki̇n, Di̇lek Kanyilmaz, Hali̇de Aslaner, Ali̇ye Baştuğ, Adalet Aypak, Pinar Öngürü, Esragül Akinci, Nevzat Mehmet Mutlu, Hurrem Bodur
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to investigate the epidemiologic characteristics, the causative microorganisms and their antimicrobial susceptibility patterns, and the prognostic risk factors for mortality in critically ill patients with ventilator-associated pneumonia (VAP). Materials and methods: In this retrospective observational study, all the critically ill patients with VAP hospitalized in a medical/surgical intensive care unit (ICU) between January 2010 and June 2015 were evaluated. Patients' demographic features and microbiological data were reviewed. Results: A total of 417 patients were clinically diagnosed with VAP; 51.1% of them were male and the average age was found as 69.9 ± 15.9 …
The Effect Of Trimetazidine On Renal Oxidative Stress In Partialand Complete Ureteral Obstructions In A Rat Model, Sema Nur Ayyildiz, Ali̇ Ayyildiz, Erdal Benli̇, Selma Cirrik, Rüştü Cankon Germi̇yanoğlu, Tevfi̇k Noyan, Abdullah Çirakoğlu
The Effect Of Trimetazidine On Renal Oxidative Stress In Partialand Complete Ureteral Obstructions In A Rat Model, Sema Nur Ayyildiz, Ali̇ Ayyildiz, Erdal Benli̇, Selma Cirrik, Rüştü Cankon Germi̇yanoğlu, Tevfi̇k Noyan, Abdullah Çirakoğlu
Turkish Journal of Medical Sciences
Background/aim: Renal oxidative stress occurs in ureteral obstructions. The purpose of this study was to investigate the effect of the antioxidant and antiischemic agent trimetazidine (TMZ) on oxidative stress following ureteral obstruction. Materials and methods: Ten groups were established. Sham groups were checked as controls after 1 and 3 weeks. The other 8 groups had partial or complete ureteral obstruction while receiving or not receiving trimetazidine (TMZ) at 5 mg/kg daily and were evaluated after either 1 week or 3 weeks. Creatinine and cystatin C measurements were performed in the serum. Malondialdehyde, myeloperoxidase, catalase, and glutathione peroxidase activity were measured …
The Effects Of Iloprost And Alprostadil On Ischemia-Reperfusion Injury In Preventing Inflammation, Tissue Degeneration, And Apoptosis In Rat Skeletal Muscle, Eli̇f Güneysu, Atacan Emre Koçman, Orhan Özati̇k, Cengi̇z Ovali, Betül Can, İbrahi̇m Özkan Alataş, Mustafa Behçet Sevi̇n
The Effects Of Iloprost And Alprostadil On Ischemia-Reperfusion Injury In Preventing Inflammation, Tissue Degeneration, And Apoptosis In Rat Skeletal Muscle, Eli̇f Güneysu, Atacan Emre Koçman, Orhan Özati̇k, Cengi̇z Ovali, Betül Can, İbrahi̇m Özkan Alataş, Mustafa Behçet Sevi̇n
Turkish Journal of Medical Sciences
Background/aim: The protective effects of prostaglandin (PG) analogs on ischemia-reperfusion (I/R) have been well documented; however, comparative studies are lacking. The aim of the present study was to determine whether iloprost or alprostadil is more effective in preventing muscle I/R injury. Materials and methods: Thirty-two rats were divided into four groups (n = 8): sham, control, IL (I/R + iloprost), and AL (I/R + alprostadil). I/R was induced by a tourniquet in the hindlimb for 3 h/3 h. The IL and AL groups received iloprost (0.5 ng kg-1 min-1) and alprostadil (0.05 μg kg-1 min-1) during reperfusion, respectively. After 6 …
Prevalence And Prognosis Of Intracranial Stenosis In Acute Ischemic Stroke;A Single Center Registry From Turkey, Mi̇ne Hayri̇ye Sorgun, Volkan Yilmaz, Çağri Ulukan, Sabi̇ha Tezcan, Müge Kuzu, İnci̇ Şule Özer, Hafi̇ze Çotur, Sefer Rzayev, Anwar Rawandi, Canan Togay Işikay
Prevalence And Prognosis Of Intracranial Stenosis In Acute Ischemic Stroke;A Single Center Registry From Turkey, Mi̇ne Hayri̇ye Sorgun, Volkan Yilmaz, Çağri Ulukan, Sabi̇ha Tezcan, Müge Kuzu, İnci̇ Şule Özer, Hafi̇ze Çotur, Sefer Rzayev, Anwar Rawandi, Canan Togay Işikay
Turkish Journal of Medical Sciences
Background/aim: Intracranial stenosis (ICS) is identified in 2.2%?70.4% of patients with ischemic stroke and transient ischemic attack. This study aimed to determine the prevalence of ICS in a single center registry from Turkey. Materials and methods: We reviewed the charts of 619 patients with acute ischemic stroke. ICS was defined as any ICS > 50% on cerebrovascular imaging. The demographic data, risk factors, NIHSS scores and C reactive protein level at admission, mortality in hospital, recurrent stroke, and mRS in the follow-up period were recorded. Results: A total of 72 (11.6%) patients with ICS (45 males (62.5%); mean age 68.3 ± …
Impact Of Ggcx Polymorphisms On Warfarin Dose Requirements In Atrial Fibrillation Patients, Nian-Xin Jiang, Ying-Hui Xu, Jing-Wen Xia, Bing Jiang, Yan-Song Li
Impact Of Ggcx Polymorphisms On Warfarin Dose Requirements In Atrial Fibrillation Patients, Nian-Xin Jiang, Ying-Hui Xu, Jing-Wen Xia, Bing Jiang, Yan-Song Li
Turkish Journal of Medical Sciences
Background/aim: Warfarin is a common anticoagulant with large interindividual differences and a narrow therapeutic range. The polymorphisms of gamma-glutamyl carboxylase (GGCX) are important genetic factors for warfarin dose requirements. Materials and methods: Polymerase chain reaction and direct sequencing methods were used to detect the GGCX rs699664 genotype in 215 atrial fibrillation (AF) patients with warfarin administration. The effects on warfarin dose by different genotypes were analyzed. A warfarin dosing algorithm was developed based on age, height, CYP2C9, VKORC1, and GGCX genotype. Results: In 215 AF patients, there were 104 cases of wild-type GG genotype (48.4%), 92 cases of GA genotype …
Obstructive Sleep Apnea Characteristics In Patients With Well-Controlled Acromegaly And Their Compliance With Positive Airway Pressure Therapy, Mehmet Sezai̇ Taşbakan, Özen Kaçmaz Başoğlu, Ilgin Yildirim Şi̇mşi̇r, Lütfi̇ye Füsun Saygili
Obstructive Sleep Apnea Characteristics In Patients With Well-Controlled Acromegaly And Their Compliance With Positive Airway Pressure Therapy, Mehmet Sezai̇ Taşbakan, Özen Kaçmaz Başoğlu, Ilgin Yildirim Şi̇mşi̇r, Lütfi̇ye Füsun Saygili
Turkish Journal of Medical Sciences
Background/aim: Acromegaly is often associated with obstructive sleep apnea syndrome (OSAS) with a frequency between 40% and 80%. The aim of the present study was to evaluate the clinical and polysomnographic characteristics of acromegaly patients with sleep apnea symptoms and to identify positive airway pressure (PAP) adherence in acromegaly patients with OSAS diagnosis.Materials and methods: Twenty-eight well-controlled acromegaly patients (17 males, mean age 48.7 $\pm$ 10.1 years) with sleep apnea symptoms were included in this prospective study. Demographic data, anthropometric measurements, and medical history were evaluated. Full-night in-laboratory polysomnography was performed.Results: Polysomnography results showed that 25 patients (89.3%) had OSAS …
How To Manage Pseudoangiomatous Stromal Hyperplasia: Our Clinical Experience, Emi̇ne Kurt, Sevi̇m Turanli, Fatma Markoç, Ali̇ Uğur Berberoğlu
How To Manage Pseudoangiomatous Stromal Hyperplasia: Our Clinical Experience, Emi̇ne Kurt, Sevi̇m Turanli, Fatma Markoç, Ali̇ Uğur Berberoğlu
Turkish Journal of Medical Sciences
Background/aim: Pseudoangiomatous stromal hyperplasia (PASH) is a rare and benign mesenchymal proliferative breast lesion. Our aim is to review the clinical and radiological features of PASH and define a standard approach for its diagnosis and management. Materials and methods: Clinical records of 35 consecutive patients with PASH were retrospectively reviewed between 2009 and 2015. Patients with clinically or radiologically detected mass and patients who underwent biopsy for other indications and were diagnosed incidentally were included in the study. Results: There were 34 female patients and one male patient with gynecomastia. Twenty-three patients had palpable masses, and 16 of them were …
Effect Of Treatment Of Iron Deficiency Anemia Onhemoglobin A1c In Type 2 Diabetic Patients, Ensieh Nasli-Esfahani, Bagher Larijani, Peyvand Amini, Robabeh Ghodsi Ghasemabadi, Rezvan Razmandeh
Effect Of Treatment Of Iron Deficiency Anemia Onhemoglobin A1c In Type 2 Diabetic Patients, Ensieh Nasli-Esfahani, Bagher Larijani, Peyvand Amini, Robabeh Ghodsi Ghasemabadi, Rezvan Razmandeh
Turkish Journal of Medical Sciences
Background/aim: Iron deficiency anemia (IDA) affects hemoglobin A1c (HbA1c) levels. This study aimed to evaluate the effect of treatment of iron deficiency anemia on hemoglobin A1c in type 2 diabetic patients.Materials and methods: Ninety type 2 diabetes mellitus (T2DM) patients with IDA were included in a randomized, placebo-controlled, single-blind clinical trial. The intervention group (n = 45) received 200 mg/day oral iron for 3 months and the control group (n = 45) received an oral placebo for the same period. Fasting blood sugar, complete blood count, and HbA1c were measured for all subjects at the beginning and the end of …
Intralesional Epidermal Growth Factor Therapy Fordiabetic Foot Ulcers: An Evaluation Of 15 Cases, Meltem Taşbakan, Ilgin Yildirim Şi̇mşi̇r, Si̇nan Mermer, Serhat Uysal, Anil Murat Öztürk, Şevki̇ Çeti̇nkalp
Intralesional Epidermal Growth Factor Therapy Fordiabetic Foot Ulcers: An Evaluation Of 15 Cases, Meltem Taşbakan, Ilgin Yildirim Şi̇mşi̇r, Si̇nan Mermer, Serhat Uysal, Anil Murat Öztürk, Şevki̇ Çeti̇nkalp
Turkish Journal of Medical Sciences
Background/aim: Intralesional recombinant epidermal growth factor (EGF) is a new treatment approach for diabetic foot ulcer, approved in 2006. EGF therapy is given as an adjunct to the standard treatment regimen of antibiotics, surgery, and hyperbaric oxygen. EGF accelerates the healing of diabetic foot ulcers and reduces healing time. This single-center study was conducted to evaluate the outcomes of intralesional EGF therapy in patients with diabetic foot ulcers.Materials and methods: We present the data of the follow-up patients treated in our clinics. Fifteen patients with diabetic foot ulcers or infections, who had been followed up and treated in our clinics, …
Efficacy Of Bispectral Index Monitoring For Prevention Of Anestheticawareness And Complications During Oocyte Pick-Up Procedure, Aykut Urfalioğlu, Mahmut Arslan, Süleyman Murat Bakacak, Hafi̇ze Öksüz, Ömer Faruk Boran, Gözen Öksüz
Efficacy Of Bispectral Index Monitoring For Prevention Of Anestheticawareness And Complications During Oocyte Pick-Up Procedure, Aykut Urfalioğlu, Mahmut Arslan, Süleyman Murat Bakacak, Hafi̇ze Öksüz, Ömer Faruk Boran, Gözen Öksüz
Turkish Journal of Medical Sciences
Background/aim: This study was planned by considering that the use of bispectral index (BIS) monitoring ensures sufficient depth of anesthesia and avoids anesthetic awareness and patient movement in the oocyte pick-up (OPU) procedure.Materials and methods: Ninety-eight patients undergoing OPU were randomly divided into 2 groups as the control group (n = 48) and BIS group (n = 50). After propofol and remifentanil induction, the control group was given additional propofol according to reaction response, while the BIS group was given propofol at BIS values of 60 and above with the aim that BIS values be 40?60. Total procedure time, recovery …