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Full-Text Articles in Medicine and Health Sciences
Signal Transduction: Rhomantic Interludes Raise Blood Pressure, Andrew P. Somlyo
Signal Transduction: Rhomantic Interludes Raise Blood Pressure, Andrew P. Somlyo
Jama S. Coartney
No abstract provided.
Effect Size And Power For Clinical Trials Using Years Of Healthy Life As The Primary Endpoint, Paula Diehr
Effect Size And Power For Clinical Trials Using Years Of Healthy Life As The Primary Endpoint, Paula Diehr
Paula Diehr
Some clinical trials perform repeated measurements on patients over time, plot those measures against time, and summarize the results in terms of the area under the curve. If the measured variable is health status, the summary outcome is sometimes referred to as years of healthy life (YHL), or quality-adjusted life years (QALY). This paper investigates some theoretical and practical aspects of randomized trials designed to assess measures such as YHL. We first derived algebraic expressions for the effect size of YHL measures under several theoretical models of the treatment's effect on health. We used these expressions to examine how the …
Isolation Of A Mannose-Binding And Ige- And Igm-Reactive Lectin From The Seeds Of Artocarpus Integer, Onn Haji Hashim
Isolation Of A Mannose-Binding And Ige- And Igm-Reactive Lectin From The Seeds Of Artocarpus Integer, Onn Haji Hashim
Onn Haji Hashim
A mannose-binding lectin, termed champedak lectin-M, was isolated from an extract of the crude seeds of champedak (Artocarpus integer). On gel filtration chromatography, the lectin eluted in a single peak at elution volumes corresponding to 64 kDa, SDS-PAGE showed the mannose-binding lectin to be composed of 16.8 kDa polypeptides with some of the polypeptides being disulphide-linked to give dimers. When tested with all isotypes of immunoglobulins, champedak lectin-M demonstrated a selective strong interaction with human IgE and IgM, and a weak interaction with IgA2, The binding interactions of lectin-M were metal ion independent. The lectin was also shown to interact …