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Full-Text Articles in Medicine and Health Sciences

Nitrous Oxide Adaptation On Gene Expression In Breast Cancer Cells, Harsh Chheda, Estevan Ruiz Limón López, Zainab Mahmood, Ankit Sharma, Tina Tran, Uzma Abdulbaseer, Farouk Alshatti, James A. Radosevich Nov 2021

Nitrous Oxide Adaptation On Gene Expression In Breast Cancer Cells, Harsh Chheda, Estevan Ruiz Limón López, Zainab Mahmood, Ankit Sharma, Tina Tran, Uzma Abdulbaseer, Farouk Alshatti, James A. Radosevich

Chemistry and Physics Faculty Proceedings, Presentations, Speeches, Lectures

Hypothesis and Objective: Genes participating in the notch signaling pathway are influenced by exposure to high nitrous oxide (HNO) levels. Notch signaling pathway genes are responsible for regulating cell fate, differentiation, and apoptosis. Dysregulation of these genes can contribute to tumorigenesis. Alterations in the expression of these genes in MCF7 breast cancer cells could help determine the effects of the notch signaling pathway on tumorigenesis as a result of exposure to nitrous oxide.

Methods: Samples of cDNA from MCF7 and MCF7-HNO cells were used in DNA microarray analysis. Qualifying genes of interest provided a p value < .05. Differentially expressed genes (DEGs) were defined and categorized using the Gene Oncology Uniprot (GO) Molecular Function database. These cells were further analyzed using a proprietary bioinformatics analysis created by our laboratory.

Results: Exposure to HNO …


Student Handbook 2018-2019, Nova Southeastern University Jan 2018

Student Handbook 2018-2019, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division 2016-2017 Catalog, Nova Southeastern University Jan 2016

Health Professions Division 2016-2017 Catalog, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog 2015-2016, Nova Southeastern University Jan 2015

Health Professions Division Catalog 2015-2016, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog 2007-2008, Nova Southeastern University Jan 2007

Health Professions Division Catalog 2007-2008, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog 2006-2007, Nova Southeastern University Jan 2006

Health Professions Division Catalog 2006-2007, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog 2005-2006, Nova Southeastern University Jan 2005

Health Professions Division Catalog 2005-2006, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog 2004-2005, Nova Southeastern University Jan 2004

Health Professions Division Catalog 2004-2005, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


College Of Medical Science Student Handbook July 2003, Nova Southeastern University Jul 2003

College Of Medical Science Student Handbook July 2003, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog 2003-2004, Nova Southeastern University Jan 2003

Health Professions Division Catalog 2003-2004, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog Academic Year 2002-2003, Nova Southeastern University Jan 2002

Health Professions Division Catalog Academic Year 2002-2003, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog Academic Year 2001-2002, Nova Southeastern University Jan 2001

Health Professions Division Catalog Academic Year 2001-2002, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog Academic Year 2000-2001, Nova Southeastern University Jan 2000

Health Professions Division Catalog Academic Year 2000-2001, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog Academic Year 1999-2000, Nova Southeastern University Jan 1999

Health Professions Division Catalog Academic Year 1999-2000, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Catalog Academic Year 1998-1999, Nova Southeastern University Jan 1998

Health Professions Division Catalog Academic Year 1998-1999, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.


Health Professions Division Academic Year 1996-1997, Nova Southeastern University Jan 1996

Health Professions Division Academic Year 1996-1997, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.