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Enhancing Cell Seeding And Osteogenesis Of Mscs On 3d Printed Scaffolds Through Injectable Bmp2 Immobilized Ecm-Mimetic Gel, Farahnaz Fahimipour, Erfan Dashtimoghadam, Mohammad Mahdi Hasani-Sadrabadi, Jessica Vargas, Daryoosh Vashaee, Doug Lobner, Tahereh S. Jafarzadeh Kashi, Behnam Ghasemzadeh, Lobat Tayebi
Enhancing Cell Seeding And Osteogenesis Of Mscs On 3d Printed Scaffolds Through Injectable Bmp2 Immobilized Ecm-Mimetic Gel, Farahnaz Fahimipour, Erfan Dashtimoghadam, Mohammad Mahdi Hasani-Sadrabadi, Jessica Vargas, Daryoosh Vashaee, Doug Lobner, Tahereh S. Jafarzadeh Kashi, Behnam Ghasemzadeh, Lobat Tayebi
Biomedical Sciences Faculty Research and Publications
Objective
Design of bioactive scaffolds with osteogenic capacity is a central challenge in cell-based patient-specific bone tissue engineering. Efficient and spatially uniform seeding of (stem) cells onto such constructs is vital to attain functional tissues. Herein we developed heparin functionalized collagen gels supported by 3D printed bioceramic scaffolds, as bone extracellular matrix (ECM)-mimetic matrices. These matrices were designed to enhance cell seeding efficiency of mesenchymal stem cells (MSCs) as well as improve their osteogenic differentiation through immobilized bone morphogenic protein 2 (BMP2) to be used for personalized bone regeneration.
Methods
A 3D gel based on heparin-conjugated collagen matrix capable of …