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Perinatal Nicotine Exposure And Programming Of Hie Sensitive Phenotype In Neonatal Rat Brains, Yong Li
Perinatal Nicotine Exposure And Programming Of Hie Sensitive Phenotype In Neonatal Rat Brains, Yong Li
Loma Linda University Electronic Theses, Dissertations & Projects
Large epidemiological and animal studies have revealed a clear association of adverse intrauterine environment with the increased risk of metabolic, cardiovascular and neurological diseases. Maternal smoking is the single most widespread perinatal insult in the world and has been associated with adverse pregnancy outcomes for mother, fetus and the newborn. Our study aims to test the hypothesis that perinatal nicotine exposure induces reprogramming of susceptibility to hypoxic ischemic brain injury in the immature brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat models: perinatal nicotine exposure model …
Effect Of Maternal Hypoxia On The Cerebral And Cardiac Tissue Remodeling, Wenni Tong
Effect Of Maternal Hypoxia On The Cerebral And Cardiac Tissue Remodeling, Wenni Tong
Loma Linda University Electronic Theses, Dissertations & Projects
Large epidemiological studies and animal studies have indicated a clear association of adverse intrauterine environment with an increased incidence of low birth weight, perinatal mortality, and cardiovascular disease in later adult life. In humans, one of the most common stresses in utero is hypoxia. The goal of this project is to test the hypothesis that fetal hypoxia causes reprogramming of MMPs and TIMPs expression patterns and activities leading to aberrant brain and heart development in the fetuses and neonates. In the first part of project, we tested the hypothesis that maternal hypoxia increases the activity of MMPs and decreases the …