Medicine and Health Sciences Commons^™

Regeneration Of Neurons In Human Brain Tissue; A Revolutionary Concept With Therapeutic Potential, Mackenzie R. Dunn

Other Undergraduate Research

There is current research to suggest that endogenous neuronal regeneration, exogenous neuronal stem cell transplantation and glial cell reprogramming could be prospective therapeutic treatments for neurodegeneration and traumatic injury. With these conditions, there is significant brain atrophy, loss of neurons and loss of synaptic connections which can have devastating effects on executive functioning, cognition, learning and memory. This review will examine these modern approaches to adult neurogenesis, and assess the viable mechanisms and future outlook of these three therapies for neurological regenerative medicine.

Exploration Of The Healthcare Conditions In The Occupied Palestinian Territories, Awatef Ayesh

Honors Projects

The occupation of Palestine by Israel has had a significant impact on the Palestinian citizens' health care services. The disparities were seen in maternal, infant, and child mortality rates, life expectancy, and measures of mental wellbeing. The health disparities are due to many factors involving economic conditions, food insecurity, environmental exposures, psychological trauma and stress, and access to health services most of which are directly or indirectly linked to the Israeli military occupation of the occupied Palestinian territories (oPt). This project explores the health indicators and examine the social determinants of health in the oPt that may be responsible for …

Evaluating The Microbial Experience Influence On Anti-Tumor Immune Response, Jessica A. Ensing

Student Summer Scholars Manuscripts

Despite the steady increase of hygienic standards, the CDC continues to report an increase of immune-mediated diseases such as allergies and asthma. Human avoidance of microbial exposure and subsequently less experienced immune systems may be the cause for this increase. We investigated if increased microbial exposure results in increased immunity to cancer (B16 melanoma) by measuring activated lymphocytes between two groups of C57Bl/6 mice: specific pathogen free (SPF) mice (which had little microbial exposure) and cohoused (COH) mice (which were exposed to numerous microbes). Previous research shows that the CoH mouse model mimics a human adult’s immune system, while the …

Literature Review On Drosophila Research In Parkinson’S Disease, Maryann Jaquith

Honors Projects

Parkinson’s disease (PD) is one of the most prevalent neurodegenerative diseases. It is characterized by its main symptom of a tremor that usually starts in one limb. The four cardinal symptoms of PD are tremor, rigidity, bradykinesia, and postural instability. While the four cardinal symptoms are all motor symptoms there are non-motor symptoms for PD which include cognitive changes, sleeping disorders, lightheadedness, early satiety, and mood disorders. PD is characterized by dopaminergic (DA) neuron loss and the accumulation of Lewy bodies (LB) which are predominantly composed of α-synuclein (α-Syn) protein.

α-Syn is a protein found abundantly in the brain. It …

Erk1/2 Do Not Phosphorylate Proteins In Mitochondria And Myofilaments, Tanner Napierala

Student Scholars Day Posters

Heart disease continues to be the most prevalent health issue in the United States. Previous studies have demonstrated the cardio-protective benefit of an increase in extracellular signal regulated kinase 1 and 2 (ERK1/2) activity in mice. In this study, genetically modified mice with knockouts of both the DUSP6 and DUSP8 genes (DKO) were used to study whether increased ERK1/2 phosphorylation in DKO mice changes the expression of these death-related proteins. We found out the increase in ERK1/2 phosphorylation mainly stayed in cytoplasm and the expression levels of BCl-2 and Bax were not altered. We also investigated whether myofilament proteins could …

Predator Odor Stress On Stress And Metabolic Endocrine, Morgan Block, Katie Wilk

Student Scholars Day Posters

It is known that the brain and gut ‘talk’ to each other, which is important for both physical and mental health as shown by associations between metabolic syndrome and mental illness in humans. Neuropeptides found in both the brain and gut are active in this communication and may mediate links between stress, metabolism, and psychopathology. This study aims to determine whether single exposure to predator odor is able to produce long-term changes in the endocrine system as measured by plasma concentrations of the “stress hormone” corticosterone and “hunger hormone” ghrelin. Male and female mice were exposed to one hour of …

Testing The Ancestral Function Of Divergent Candida Albicans Virulence-Associated Proteins Via Expression In Saccharomyces Cerevisiae Mutants, Curtis Mack

Student Scholars Day Posters

Candida albicans is an opportunistic fungal pathogen and a member of the normal human microbiota. It is closely related to the harmless fungus, Saccharomyces cerevisiae. Some genes associated with the virulent nature of C. albicans are similar to genes in S. cerevisiae. Three of these genes, PHO13, NRG1, and TUP1 are known to repress the change from yeast to filamentous growth in C. albicans, an important virulence trait. However, similar genes in S. cerevisiae are known to have functional differences. Our goal was to see if the ancestral function of these genes have drifted apart by examining …

The Role Of Erk 1/2 Proteins In Diabetic Cardiomyopathy, Megan Coble

Student Scholars Day Posters

Diabetes is characterized by inadequate utilization of glucose due to a lack of insulin. Cardiomyopathy is defined as chronic disease of the heart muscle. A correlation between diabetes and the onset of cardiomyopathy has been suggested though a complete understanding of this relationship remains to be determined. Induction of diabetes within mice via the injection of streptozotocin will allow for thorough investigation of this correlation. Enhancement of the proteins ERK 1/2, via the deletion of genes DUSP 6/8, has been shown to be a protective agent against various heart pathologies. By inducing diabetes within both wild type and DUSP 6/8 …

Scoliosis And Its Treatment In Adults, Hilary Skalski

Student Scholars Day Posters

Scoliosis is a greater than ten-degree curve in the spine in the coronal plane. There are many types of scoliosis, with the most common being adolescent idiopathic. The most common type in adults is degenerative scoliosis, caused by the wear and tear of the spine. In adults, treatment options are selected based on symptoms caused by the curvature. Treatments include lifestyle changes, medications, physical therapy and surgery. Two common surgical treatments are a laminectomy for decompression or a spinal fusion. The dissection of a 92-year-old male cadaver revealed scoliosis of lumbar vertebrae one through five (L1-5). A post-mortem laminectomy then …

Early Cell-Cell Coupling Impairs Stem Cell Retention When Co-Cultured With Hypoxic Cardiomyocytes, Jack Tietema

Student Scholars Day Posters

Rationale: Bone marrow-derived mesenchymal stem cells (BM-MSC) induce beneficial effects in the heart following hypoxia but loss of these cells would diminish their effect. We hypothesized that coupling between BM-MSC and cardiomyocytes (CM) through gap junctions (GJ) during hypoxia may play an important role in stem cell retention. Methods and Results: Both human and murine BM-MSC express connexin43 (Cx43), a critical protein in the formation of GJ. FACS analysis revealed that BM-MSC exhibited a significant reduction in apoptosis (3-5 fold; p

The Effects Of Saido Learning On The Cognition Of Patients With Dementia: A Retrospective Study, Stephanie N. Laduke

Honors Projects

SAIDO Learning is a cognitive and social intervention developed by the Kumon Institute in 2004 to slow the progress of symptoms in patients diagnosed with dementia. Today, twenty-three nursing facilities nationwide utilize SAIDO Learning. The data in this retrospective study compare the baseline Mini-Mental State Exam (MMSE) scores to the MMSE scores obtained six months after SAIDO Learning is implemented from patients diagnosed with dementia at Waterford Place in Jenison, Michigan. These scores are reassessed every 6 months as a standard of care. The data was deidentified by the staff of Waterford Place before given to the research team. A …

Cold Exposure Induces Dynamic, Heterogeneous Alterations In Human Brown Adipose Tissue Lipid Content, Crystal L. Coolbaugh, Bruce M. Damon, Emily C. Bush, E Brian Welch, Theodore F. Towse

Peer Reviewed Articles

Brown adipose tissue undergoes a dynamic, heterogeneous response to cold exposure that can include the simultaneous synthesis, uptake, and oxidation of fatty acids. The purpose of this work was to quantify these changes in brown adipose tissue lipid content (fat-signal fraction (FSF)) using fat-water magnetic resonance imaging during individualized cooling to 3 °C above a participant’s shiver threshold. Eight healthy men completed familiarization, perception-based cooling, and MRI-cooling visits. FSF maps of the supraclavicular region were acquired in thermoneutrality and during cooling (59.5 ± 6.5 min). Brown adipose tissue regions of interest were defined, and voxels were grouped into FSF decades …

Shape Ontogeny Of The Distal Femur In The Hominidae With Implications For The Evolution Of Bipedality, Melissa Tallman

Funded Articles

Heterochrony has been invoked to explain differences in the morphology of modern humans as compared to other great apes. The distal femur is one area where heterochrony has been hypothesized to explain morphological differentiation among Plio-Pleistocene hominins. This hypothesis is evaluated here using geometric morphometric data to describe the ontogenetic shape trajectories of extant hominine distal femora and place Plio-Pleistocene hominins within that context. Results of multivariate statistical analyses showed that in both Homo and Gorilla, the shape of the distal femur changes significantly over the course of development, whereas that of Pan changes very little. Development of the …

To Pair Or Not To Pair: Sources Of Social Variability With White-Faced Saki Monkeys (Pithecia Pithecia) As A Case Study, Cynthia Thompson

Funded Articles

Intraspecific variability in social systems is gaining increased recognition in primatology. Many primate species display variability in pair-living social organizations through incorporating extra adults into the group. While numerous models exist to explain primate pair-living, our tools to assess how and why variation in this trait occurs are currently limited. Here I outline an approach which: (i) utilizes conceptual models to identify the selective forces driving pair-living; (ii) outlines novel possible causes for variability in social organization; and (iii) conducts a holistic species-level analysis of social behavior to determine the factors contributing to variation in pair-living. A case study on …

Autism Awareness: Debunking Misconceptions, Nicole Summers

Honors Projects

No abstract provided.

Evaluation Of A New Method Of Fossil Retrodeformation By Symmetrization: Crania Of Papionins (Primates, Cercopithecidae) As A Test Case, Melissa Tallman, Andrea Morrow, Nina Amenta, Eric Delson, Stephen Frost, Deboshmita Ghosh, Zachary Klukkert, Gary Sawyer

Funded Articles

Diagenetic distortion can be a major obstacle to collecting quantitative shape data on paleontological specimens, especially for three-dimensional geometric morphometric analysis. Here we utilize the recently -published algorithmic symmetrization method of fossil reconstruction and compare it to the more traditional reflection & averaging approach. In order to have an objective test of this method, five casts of a female cranium of Papio hamadryas kindae were manually deformed while the plaster hardened. These were subsequently “retrodeformed” using both algorithmic symmetrization and reflection & averaging and then compared to the original, undeformed specimen. We found that in all cases, algorithmic retrodeformation improved …

A Community Of Practice: Librarians In A Biomedical Research Network, Danielle P. De Jager-Loftus, David Midyette, Barbara Harvey

Scholarly Papers and Articles

Providing library and reference services within a biomedical research community presents special challenges for librarians, especially those in historically lower-funded states. These challenges can include understanding needs, defining and communicating the library’s role, building relationships, and developing and maintaining general and subject specific knowledge. This article describes a biomedical research network and the work of health sciences librarians at the lead intensive research institution with librarians from primarily undergraduate institutions and tribal colleges and universities. Applying the concept of a “community of practice” to a collaborative effort suggests how librarians can work together to provide effective reference services to researchers …

Visual Learning And Discrimination Of Abstract Visual Shapes By Crayfish, Matthew J. Boeve, Daniel A. Bergman

Student Summer Scholars Manuscripts

In nature, animals commonly experience multiple combinations of stimuli at various points in time. When two or more seemingly unrelated stimuli are detected at the same time using different sensory systems, there is the potential for an association to form between the stimuli. The animal may learn and show a response originally associated with one stimulus when it now detects the second stimulus. These stimuli are the unconditioned and conditioned stimulus of classical and operant conditioning. Many species of animals are known to learn via operant conditioning and a variety of responses can become associated with formerly neutral stimuli. Crayfish …

The Notch Signaling Pathway Drives Astrogliogenesis By Regulating The Expression Of The Transcription Factors Nfia And Sox9, Derek Janssens, Merritt Taylor

Student Summer Scholars Manuscripts

In the developing nervous system the Notch signaling pathway has recently been shown to be necessary and sufficient for neural stem cells to differentiate into astroctyes, a process called astrogliogenesis. However, the mechanism of how Notch signaling regulates this process has not yet been characterized. Our lab is examining whether Notch signaling controls the expression of the genes NFIA and Sox9 which are known to regulate astogliogenesis. These candidate genes were selected because their DNA sequences have characteristics that indicate their expression could be controlled by Notch through a transcriptional complex of Notch and other proteins, including the DNA binding …