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Wave 2 Strains Of Atypical Vibrio Cholerae El Tor Caused The 2009-2011 Cholera Outbreak In Papua New Guinea, Andrew R. Greenhill, Ankur Mutreja, Dieter Bulach, Matthew J. Belousoff, Marinjho H. Jonduo, Deirdre A. Collins, Monalisa P. Kas, Johanna Wapling, Torsten Seemann, Alice Lafana, Gordon Dougan, Mark V. Brown, Paul F. Horwood
Wave 2 Strains Of Atypical Vibrio Cholerae El Tor Caused The 2009-2011 Cholera Outbreak In Papua New Guinea, Andrew R. Greenhill, Ankur Mutreja, Dieter Bulach, Matthew J. Belousoff, Marinjho H. Jonduo, Deirdre A. Collins, Monalisa P. Kas, Johanna Wapling, Torsten Seemann, Alice Lafana, Gordon Dougan, Mark V. Brown, Paul F. Horwood
Research outputs 2014 to 2021
Vibrio cholerae is the causative agent of cholera, a globally important human disease for at least 200 years. In 2009-2011, the first recorded cholera outbreak in Papua New Guinea (PNG) occurred. We conducted genetic and phenotypic characterization of 21 isolates of V. cholerae, with whole-genome sequencing conducted on 2 representative isolates. The PNG outbreak was caused by an atypical El Tor strain harbouring a tandem repeat of the CTX prophage on chromosome II. Whole-genome sequence data, prophage structural analysis and the absence of the SXT integrative conjugative element was indicative that the PNG isolates were most closely related to strains …