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Full-Text Articles in Medicine and Health Sciences
Lbnp Reduces Cerebral Perfusion But Does Not Impact Executive Function, James Van Riesen
Lbnp Reduces Cerebral Perfusion But Does Not Impact Executive Function, James Van Riesen
Electronic Thesis and Dissertation Repository
A growing body of literature has demonstrated that a single bout of aerobic exercise and/or hypercapnic manipulations increase cerebral blood flow (CBF) and are linked to a transient (i.e.,min) post-intervention executive function (EF) benefit. However, there are no direct studies examining whether a transient decrease in CBF elicits a post-intervention EF decrement. Accordingly, my thesis employed 10-min single bout manipulations of -30 mmHg and -50 mmHg lower-body negative pressure (LBNP) to determine whether a transient reduction in CBF impacts EF. LBNP was applied as it renders sub-atmospheric pressure to the lower limbs and redistributes blood from the upper to lower …
Exercise Protects Against Congenital Heart Defects Induced By Pregestational Diabetes, Tana Saiyin
Exercise Protects Against Congenital Heart Defects Induced By Pregestational Diabetes, Tana Saiyin
Electronic Thesis and Dissertation Repository
Pregestational diabetes is a risk factor for birth defects, with diabetic women having a four times higher risk of producing children with congenital heart defects (CHDs). This is concerning because the prevalence of diabetes is growing at epidemic proportions. The purpose of this thesis is to investigate whether exercise can also reduce hyperglycemia-induced CHDs and determine the underlying mechanism. Endothelial nitric oxide synthase (eNOS) is a critical enzyme for normal cardiogenesis that can be upregulated with exercise in adult cardiovascular tissue. However, whether maternal exercise can regulate fetal eNOS and affect heart development has yet to be studied. In this …
The Effect Of Aerobic Exercise Training On Hepatic Glycogen Metabolism In Type 1 Diabetic Rats, Michael Murray
The Effect Of Aerobic Exercise Training On Hepatic Glycogen Metabolism In Type 1 Diabetic Rats, Michael Murray
Electronic Thesis and Dissertation Repository
The purpose of this investigation was to determine if ten weeks of aerobic exercise training could increase hepatic glycogen storage in rats with Type 1 Diabetes Mellitus (T1DM) and whether elevated hepatic glycogen content is associated with alterations in glycogenic proteins and insulin signaling. Rats were divided into control-sedentary, control-exercised, T1DM-sedentary and T1DM-exercised groups. Animals from each group underwent a euglycemic-hyperinsulinemic clamp at the conclusion of the study. Exercise training consisted of treadmill running at 27m/min, 6% incline for 1hr, five days/week for ten weeks. T1DM rats had lower liver glycogen concentrations than control rats and glycogen was not increased …