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Full-Text Articles in Medicine and Health Sciences
Protocadherin-19 Expression And Function In Vertebrate Brain Review, Makana Mcguire
Protocadherin-19 Expression And Function In Vertebrate Brain Review, Makana Mcguire
Williams Honors College, Honors Research Projects
For this project, a systematic review will be conducted on published studies on protocadherin-19 expression and function in vertebrate central nervous system development in the last 10 years. Protocadherin-19 (pcdh19) is a member of the cadherin superfamily. Cadherins are calcium-dependent cell adhesion molecules show to play important roles in vertebrate tissue development including the formation of the central nervous system. Understanding molecular and cellular mechanisms underlying the function of pcdh19 will help aid in understanding disease(s) caused by malfunction of this molecule, and lead to potential strategies for treatment. Data will be collected via online search of databases. The project …
Neural Stem Cell Metabolic Changes In The Presence Of Interferon-Gamma, Dylan Mckibben
Neural Stem Cell Metabolic Changes In The Presence Of Interferon-Gamma, Dylan Mckibben
Williams Honors College, Honors Research Projects
Spinal cord injury results in significant disability and health care costs due to an inability of the mature central nervous system to regenerate. One potential therapy would be implantation of neural stem cells to the injury site and stimulation of their differentiation to mature neurons. Previous work has shown that the cytokine interferon-gamma can promote this process; however, the signaling pathways induced in neural stem cells have not been well-defined. This proposal examines neural stem cell metabolic responses to signaling induced by interferon-gamma. Two questions will be answered: i) What specific metabolic pathway is activated to guide neural stem cell …