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Full-Text Articles in Medicine and Health Sciences
The Tumor Suppressor Tere1 (Ubiad1) Prenyltransferase Regulates The Elevated Cholesterol Phenotype In Castration Resistant Prostate Cancer By Controlling A Program Of Ligand Dependent Sxr Target Genes., William J. Fredericks, Jorge Sepulveda, Priti Lai, John E. Tomaszewski, Ming-Fong Lin, Terry Mcgarvey, Frank J. Rauscher, S. Bruce Malkowicz
The Tumor Suppressor Tere1 (Ubiad1) Prenyltransferase Regulates The Elevated Cholesterol Phenotype In Castration Resistant Prostate Cancer By Controlling A Program Of Ligand Dependent Sxr Target Genes., William J. Fredericks, Jorge Sepulveda, Priti Lai, John E. Tomaszewski, Ming-Fong Lin, Terry Mcgarvey, Frank J. Rauscher, S. Bruce Malkowicz
Journal Articles: Biochemistry & Molecular Biology
Castrate-Resistant Prostate Cancer (CRPC) is characterized by persistent androgen receptor-driven tumor growth in the apparent absence of systemic androgens. Current evidence suggests that CRPC cells can produce their own androgens from endogenous sterol precursors that act in an intracrine manner to stimulate tumor growth. The mechanisms by which CRPC cells become steroidogenic during tumor progression are not well defined. Herein we describe a novel link between the elevated cholesterol phenotype of CRPC and the TERE1 tumor suppressor protein, a prenyltransferase that synthesizes vitamin K-2, which is a potent endogenous ligand for the SXR nuclear hormone receptor. We show that 50% …