Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Ad16 (1)
- Bone formation (1)
- Bone resorption (1)
- Crohn’s disease (1)
- Genome stability (1)
-
- Hurlers syndrome (1)
- Inflammatory bowel disease (1)
- Lysosomal storage disorder (1)
- Mucopolysaccardosis (1)
- Nucleotide excision repair (1)
- PINP (1)
- Rad5 (1)
- Snf2/swi2 atpase (1)
- TRAP5b (1)
- Tumor necrosis factor alpha (1)
- Tumor necrosis factor alpha converting enzyme (1)
- Ulcerative colitis (1)
- Α-L-iduronidase bone remodeling (1)
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
A Biologically Active Tnf-Alpha Inhibitor Fails To Suppress Colitis In Balb/C Mice, Stephanie E. Biel
A Biologically Active Tnf-Alpha Inhibitor Fails To Suppress Colitis In Balb/C Mice, Stephanie E. Biel
MSU Graduate Theses
Tumor necrosis factor a (TNFα), a potent inflammatory cytokine, has long been established as a major driving force for pathologic inflammation. Currently, anti-TNFα therapies are the standard in Inflammatory Bowel Disease (IBD) management; however, one-third of IBD patients fail to respond to anti-TNFα therapies. Previous data from this lab indicate that TNFα Converting Enzyme (TACE) inhibition does not ameliorate colitis in BALB/C mice. Thus, we hypothesized that TNFα is not a critical component in the BALB/C model of colitis. To test this, acute colitis was induced in BALB/C mice by consumption of 5% dextran sulfate sodium (DSS) in drinking water …
Characterization Of The Skeletal Phenotype In Idua-W392x Knock-In Mice: Bone Metabolism Biomarkers, Christina J. Owensby
Characterization Of The Skeletal Phenotype In Idua-W392x Knock-In Mice: Bone Metabolism Biomarkers, Christina J. Owensby
MSU Graduate Theses
Mucopolysaccharidosis Type I (MPS I, Hurlers Syndrome) is a lysosomal storage disease caused by a deficiency of alpha-L-iduronidase (IDUA). IDUA catalyzes the degradation of the two glycosaminoglycans (GAGs); heparin sulfate (HS) and demantan sulfate (DS). The accumulation of HS and DS makes MPS I progressive with inevitable degeneration of multiple organ systems. Accumulated excess of GAGs on the skeletal system causes dysostosis multiplex, atlantoaxial instability, thoracolumbar kyphosis, genu valgum, acetabular dysplasia, and short stature. Skeletal biomarkers of bone formation and bone resorption were compared in wild-type, heterozygous, and IDUAW392X mice. To investigate osteoblast activity, levels of the bone formation marker …
Identification And Characterization Of Dna Repair Snf2/Swi2 Atpases In Tetrahymena Thermophila, Andrew Francis Morin
Identification And Characterization Of Dna Repair Snf2/Swi2 Atpases In Tetrahymena Thermophila, Andrew Francis Morin
MSU Graduate Theses
The Snf2/Swi2 ATPases Rad5 and Rad16 have been shown to play vital roles in a number of DNA repair pathways. In both Saccharomyces cerevisiae and human cell lines, Rad5 homologs (SHPRH, HLTF) have been shown to function in DNA double strand break (DSB) repair along with pathways that repair damage after replication. The function of Rad16, unlike Rad5, has been found only in lower eukaryotes such as Saccharomyces, despite the fact that it plays an essential role in nucleotide excision repair (NER), and more specifically in the repair of silenced areas of the genome. In order to more fully understand …