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Full-Text Articles in Medicine and Health Sciences
China Suboptimal Health Cohort Study: Rationale, Design And Baseline Characteristics, Youxin Wang, Siqi Ge, Yuxiang Yan, Anxin Wang, Zhongyao Zhao, Xinwei Yu, Jing Qui, Mohamed Ali Alzain, Hao Wang, Honghong Fang, Qing Gao, Manshu Song, Jie Zhang, Yong Zhou, Wei Wang
China Suboptimal Health Cohort Study: Rationale, Design And Baseline Characteristics, Youxin Wang, Siqi Ge, Yuxiang Yan, Anxin Wang, Zhongyao Zhao, Xinwei Yu, Jing Qui, Mohamed Ali Alzain, Hao Wang, Honghong Fang, Qing Gao, Manshu Song, Jie Zhang, Yong Zhou, Wei Wang
Research outputs 2014 to 2021
Background:
Suboptimal health status (SHS) is a physical state between health and disease, characterized by the perception of health complaints, general weakness, chronic fatigue and low energy levels. SHS is proposed by the ancient concept of traditional Chinese medicine (TCM) from the perspective of preservative, predictive and personalized (precision) medicine. We previously created the suboptimal health status questionnaire 25 (SHSQ-25), a novel instrument to measure SHS, validated in various populations. SHSQ-25 thus affords a window of opportunity for early detection and intervention, contributing to the reduction of chronic disease burdens.
Methods/design:
To investigate the causative effect of SHS in non-communicable …
Expression Of Cell-Surface Marker Abcb5 Causes Characteristic Modifications Of Glucose, Amino Acid And Phospholipid Metabolism In The G3361 Melanoma-Initiating Cell Line, Norbert W. Lutz, Pallavi Banerjee, Brian J. Watson, Jie Ma, Patrick J. Cozzone, Markus H. Frank
Expression Of Cell-Surface Marker Abcb5 Causes Characteristic Modifications Of Glucose, Amino Acid And Phospholipid Metabolism In The G3361 Melanoma-Initiating Cell Line, Norbert W. Lutz, Pallavi Banerjee, Brian J. Watson, Jie Ma, Patrick J. Cozzone, Markus H. Frank
Research outputs 2014 to 2021
We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for melanoma-initiating cells, on cellular metabolism. Metabolic profiles for two groups of human G3361 melanoma cells were compared, i.e. wildtype melanoma cells with intact ABCB5 expression (ABCB5-WT) and corresponding melanoma cell variants with inhibited ABCB5 expression, through shRNA-mediated gene knockdown (ABCB5-KD). A comprehensive metabolomic analysis was performed by using proton and phosphorus NMR spectroscopy of cell extracts to examine water-soluble metabolites and lipids. Parametric and non-parametric statistical analysis of absolute and relative metabolite levels yielded significant differences for …