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Bioinformatics analysis

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Identification Of Multiple Hub Genes In Acute Kidney Injury After Kidney Transplantation By Bioinformatics Analysis, Sang Wook Kang, Sung Wook Kang, Ju Yeon Ban, Min Su Park May 2022

Identification Of Multiple Hub Genes In Acute Kidney Injury After Kidney Transplantation By Bioinformatics Analysis, Sang Wook Kang, Sung Wook Kang, Ju Yeon Ban, Min Su Park

School of Graduate Studies Faculty Publications

Background and Objectives: The molecular mechanisms of the development of acute kidney injury (AKI) after kidney transplantation are not yet clear. The aim of this study was to confirm the genes and mechanisms related to AKI after transplantation. Materials and Methods: To investigate potential genetic targets for AKI, an analysis of the gene expression omnibus database was used to identify key genes and pathways. After identification of differentially expressed genes, Kyoto En-cyclopedia of Genes and Genome pathway enrichment analyses were performed. We identified the hub genes and established the protein–protein interaction network. Results: Finally, we identified 137 differentially expressed genes …