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Repressor Element-1 Silencing Transcription Factor/Neuronal Restrictive Silencer Factor (Rest/Nrsf) Can Regulate Hsv-1 Immediate-Early Transcription Via Histone Modification, Rajeswara C. Pinnoji, Gautam R. Bedadala, Beena George, Thomas C. Holland, James M. Hill, Shao-Chung V. Hsia
Repressor Element-1 Silencing Transcription Factor/Neuronal Restrictive Silencer Factor (Rest/Nrsf) Can Regulate Hsv-1 Immediate-Early Transcription Via Histone Modification, Rajeswara C. Pinnoji, Gautam R. Bedadala, Beena George, Thomas C. Holland, James M. Hill, Shao-Chung V. Hsia
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
During primary infection of its human host, Herpes Simplex Virus Type-1 (HSV-1) establishes latency in neurons where the viral genome is maintained in a circular form associated with nucleosomes in a chromatin configration. During latency, most viral genes are silenced, although the molecular mechanisms responsible for this are unclear. We hypothesized that neuronal factors repress HSV-1 gene expression during latency. A search of the HSV-1 DNA sequence for potential regulatory elements identified a Repressor Element-1/Neuronal Restrictive Silencer Element (RE-1/NRSE) located between HSV-1 genes ICP22 and ICP4. We predicted that the Repressor Element Silencing Transcription Factor/Neuronal Restrictive Silencer Factor …