Medicine and Health Sciences Commons^™

Induction Of Lipid Bodies In Leishmania Infantum-Infected C57bl/6 Macrophages Of Male Versus Female Origin, Victor A. Soupene, Ryan D. Lockard, Mary E. Wilson, Nilda E. Rodriguez

Research in the Capitol

Worldwide, 12 million people are infected with Leishmania spp. parasites. Leishmania are transmitted by the bite of sand flies. The parasite is internalized by immune cells where they develop, reproduce, and spread to new immune cells causing disease. Epidemiological studies have shown that males are more likely to develop disease. We recently demonstrated that Leishmania infantum survive better in immune cells of male origin than in cells derived from females. We also showed that L. infantum infection is characterized by fat accumulation. Additional experiments have shown that infected immune cells from males accumulate more fat than cells from females. We …