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- Animal cell; animal experiment; animal model; animal tissue; article; autopsy; cell assay; cell fate; cell survival; controlled study; flow cytometry; fluorescence microscopy; gene expression profiling; gene expression regulation; genetic transcription; immune clearance; immunological tolerance; in vivo study; microtubule; mouse; nerve cell; nerve cell necrosis; nerve fiber growth; neuropathology; nonhuman; rabies; Rabies virus; real time polymerase chain reaction; symptomatology; viral clearance; virus isolation (1)
- Animal cell; animal tissue; article; bacterial infection; bactericidal activity; controlled study; endocytosis; Escherichia coli; exocytosis; host pathogen interaction; internalization; mast cell; mast cell degranulation; mediator release; mouse; nonhuman; phagocytosis; phagosome; protection; protein analysis; protein expression; protein function; protein localization; rat (1)
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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Immune Clearance Of Attenuated Rabies Virus Results In Neuronal Survival With Altered Gene Expression., Emily A Gomme, Christoph Wirblich, Sankar Addya, Glenn F Rall, Matthias J Schnell
Immune Clearance Of Attenuated Rabies Virus Results In Neuronal Survival With Altered Gene Expression., Emily A Gomme, Christoph Wirblich, Sankar Addya, Glenn F Rall, Matthias J Schnell
Department of Microbiology and Immunology Faculty Papers
Rabies virus (RABV) is a highly neurotropic pathogen that typically leads to mortality of infected animals and humans. The precise etiology of rabies neuropathogenesis is unknown, though it is hypothesized to be due either to neuronal death or dysfunction. Analysis of human brains post-mortem reveals surprisingly little tissue damage and neuropathology considering the dramatic clinical symptomology, supporting the neuronal dysfunction model. However, whether or not neurons survive infection and clearance and, provided they do, whether they are functionally restored to their pre-infection phenotype has not been determined in vivo for RABV, or any neurotropic virus. This is due, in part, …
Effects Of Apoptotic Cell Accumulation Caused By Mer Deficiency On Germinal Center B Cells And Helper T Cells, Tahsin N. Khan, Eric B. Wong, Ziaur S.M. Rahman
Effects Of Apoptotic Cell Accumulation Caused By Mer Deficiency On Germinal Center B Cells And Helper T Cells, Tahsin N. Khan, Eric B. Wong, Ziaur S.M. Rahman
Department of Microbiology and Immunology Faculty Papers
Mer (MerTK), a member of the Tyro-3/Axl/Mer subfamily receptor tyrosine kinases, expression on phagocytes facilitates their clearance of apoptotic cells (ACs). Mer expression in germinal centers (GCs) occurs predominantly on tingible body macrophages. B and T cells do not express Mer. Mer deficiency (Mer-/-) results in the accumulation of ACs in GCs and augmented antibody-forming cell (AFC), GC and IgG2 Ab responses against T-dependent (TD) Ag. Here, we show that AC accumulation in GCs and elevated AFC, GC and IgG2 Ab responses in Mer-/- mice lasted for at least 80 days after immunization with NP-OVA. Enhanced responses and AC accumulation …
Hiv Rna Suppression And Immune Restoration: Can We Do Better?, Marilia Rita Pinzone, Michelino Di Rosa, Bruno Cacopardo, Giuseppe Nunnari
Hiv Rna Suppression And Immune Restoration: Can We Do Better?, Marilia Rita Pinzone, Michelino Di Rosa, Bruno Cacopardo, Giuseppe Nunnari
Department of Microbiology and Immunology Faculty Papers
HAART has significantly changed the natural history of HIV infection: patients receiving antiretrovirals are usually able to control viremia, even though not all virological responders adequately recover their CD4+ count. The reasons for poor immune restoration are only partially known and they include genetic, demographic and immunologic factors. A crucial element affecting immune recovery is immune activation, related to residual viremia; indeed, a suboptimal virological control (i.e., low levels of plasma HIV RNA) has been related with higher levels of chronic inflammation and all-cause mortality. The sources of residual viremia are not yet completely known, even though the most important …
A Novel Function For Snap29 (Synaptosomal-Associated Protein Of 29 Kda) In Mast Cell Phagocytosis., Jordan Wesolowski, Vernon Caldwell, Fabienne Paumet
A Novel Function For Snap29 (Synaptosomal-Associated Protein Of 29 Kda) In Mast Cell Phagocytosis., Jordan Wesolowski, Vernon Caldwell, Fabienne Paumet
Department of Microbiology and Immunology Faculty Papers
Mast cells play a critical role in the innate immune response to bacterial infection. They internalize and kill a variety of bacteria and process antigen for presentation to T cells via MHC molecules. Although mast cell phagocytosis appears to play a significant role during bacterial infection, little is known about the proteins involved in its regulation. In this study, we demonstrate that the SNARE protein SNAP29 is involved in mast cell phagocytosis. SNAP29 is localized in the endocytic pathway and is transiently recruited to Escherichia coli (E. coli)-containing phagosomes. Interestingly, overexpression of SNAP29 significantly increases the internalization and killing of …
Evidence That The Density Of Self Peptide-Mhc Ligands Regulates T-Cell Receptor Signaling., Nadia Anikeeva, Dimitry Gakamsky, Jørgen Schøller, Yuri Sykulev
Evidence That The Density Of Self Peptide-Mhc Ligands Regulates T-Cell Receptor Signaling., Nadia Anikeeva, Dimitry Gakamsky, Jørgen Schøller, Yuri Sykulev
Department of Microbiology and Immunology Faculty Papers
Noncognate or self peptide-MHC (pMHC) ligands productively interact with T-cell receptor (TCR) and are always in a large access over the cognate pMHC on the surface of antigen presenting cells. We assembled soluble cognate and noncognate pMHC class I (pMHC-I) ligands at designated ratios on various scaffolds into oligomers that mimic pMHC clustering and examined how multivalency and density of the pMHCs in model clusters influences the binding to live CD8 T cells and the kinetics of TCR signaling. Our data demonstrate that the density of self pMHC-I proteins promotes their interaction with CD8 co-receptor, which plays a critical role …