Medicine and Health Sciences Commons^™

Notch1 Gain Of Function In Germ Cells Causes Failure Of Spermatogenesis In Male Mice, Zaohua Huang, Bryan Rivas, Alexander I. Agoulnik

HWCOM Faculty Publications

NOTCH1 is a member of the NOTCH receptor family, a group of single-pass trans-membrane receptors. NOTCH signaling is highly conserved in evolution and mediates communication between adjacent cells. NOTCH receptors have been implicated in cell fate determination, as well as maintenance and differentiation of stem cells. In the mammalian testis expression of NOTCH1 in somatic and germ cells has been demonstrated, however its role in spermatogenesis was not clear. To study the significance of NOTCH1 in germ cells, we applied a cre/loxP approach in mice to induce NOTCH1 gain- or loss-of function specifically in male germ cells. Using a Stra8-icre …

Arsenic Transport By Zebrafish Aquaglyceroporins, Mohamad Hamdi, Marco A. Sanchez, Lauren C. Beene, Qianyong Liu, Scott M. Landfear, Barry P. Rosen, Zijuan Liu

HWCOM Faculty Publications

Background

Arsenic is one of the most ubiquitous toxins and endangers the health of tens of millions of humans worldwide. It is a mainly a water-borne contaminant. Inorganic trivalent arsenic (As^III) is one of the major species that exists environmentally. The transport of As^III has been studied in microbes, plants and mammals. Members of the aquaglyceroporin family have been shown to actively conduct As^III and its organic metabolite, monomethylarsenite (MAs^III). However, the transport of As^III and MAs^III in in any fish species has not been characterized.

Results

In this study, five members …