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Full-Text Articles in Medicine and Health Sciences
Comparing Roche Linear Array® To Next Generation Sequencing For Hpv Genotype Identification, Luke Konur, Ashley Winters, Brock Williams, Meng Luo, Melody Baddoo, Jennifer Cameron
Comparing Roche Linear Array® To Next Generation Sequencing For Hpv Genotype Identification, Luke Konur, Ashley Winters, Brock Williams, Meng Luo, Melody Baddoo, Jennifer Cameron
Medical Student Research Poster Symposium
BACKGROUND: Human papillomavirus (HPV) is known to be a causative agent in most cervical neoplasia, thus identifying HPV in a patient’s cervical swab is an important step in detecting risk for cervical cancer and preventing further development. The Linear Array Genotyping Test (LA) from Roche is a colorimetric reverse line blot hybridization array that detects 37 genotypes of HPV. The LA has been the standard assay used in research for HPV genotyping over the past two decades and has recently been discontinued. Newer highthroughput assays like Next Generation Sequencing (NGS) have broadened the variety of HPV types that can be …
Longitudinal Shotgun Metagenomic Analysis Of The Vaginal Microbiome During The Onsetof Bacterial Vaginosis, John W. Lammons, Jacob H. Elnagger, Evelyn Toh, Amy Dong, Kristal J. Aaron, Meng Luo, Ashutosh Tamhane, Elliot J. Lefkowitz, David E. Nelson, Christina A. Muzny, Christopher M. Taylor
Longitudinal Shotgun Metagenomic Analysis Of The Vaginal Microbiome During The Onsetof Bacterial Vaginosis, John W. Lammons, Jacob H. Elnagger, Evelyn Toh, Amy Dong, Kristal J. Aaron, Meng Luo, Ashutosh Tamhane, Elliot J. Lefkowitz, David E. Nelson, Christina A. Muzny, Christopher M. Taylor
Medical Student Research Poster Symposium
Introduction: Bacterial Vaginosis (BV) is a common disorder associated with the vaginal microbiome characterized by the displacement of lactobacillus with an overgrowth of anaerobes. Symptomatic cases can be associated with Pelvic Inflammatory Disease (PID), complications with pregnancy, and greater susceptibility to sexually transmitted infections. In cases where antibiotics are needed to treat BV, recurrence commonly occurs within 3 months to a year. Despite the prevalence of BV, the specific mechanism associated with the onset is unclear. In this pilot study we utilized shotgun metagenomics to identify the discrete changes occurring in the vaginal microbiome leading up to the onset of …