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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Killer Cell Activation By A Novel Multifunctional Protein: An Immuno/Gene Therapy For Cancer, Ashlee Tietje
Killer Cell Activation By A Novel Multifunctional Protein: An Immuno/Gene Therapy For Cancer, Ashlee Tietje
All Dissertations
One of the characteristics of advanced tumors is the evasion of the immune system. There are multiple methods that tumor cells employ to achieve this including reducing the expression of activating ligands on the cell surface and a shift in the tumor microenvironment toward pro-tumor cytokines. The purpose of this research is to develop a novel bifunctional fusion protein that will target these two deficiencies in the tumor microenvironment and activate killer cells that are already present. The proposed protein combines the extracellular domain of a ligand for the killer cell activating receptor NKG2D and Interleukin-12 (IL-12). It is hypothesized …
The Effects Of Conjugated Linoleic Acid Supplementation On Lipopolysaccharide-Challenged Synoviocytes, Allison Millican
The Effects Of Conjugated Linoleic Acid Supplementation On Lipopolysaccharide-Challenged Synoviocytes, Allison Millican
All Theses
Osteoarthritis is one of the leading causes of lameness in the athletic horse. Cases of equine osteoarthritis typically present with synovitis, or inflammation of the synovium. This inflammation in the synovium leads to the production of inflammatory cytokines and eicosanoids. Although these downstream products can be beneficial, overproduction can lead to degradation of cartilage and joint disease. Opportunities to help mitigate or decrease inflammation within the joint are of current interest to the equine industry. One method being investigated is nutritional supplementation. The anti-inflammatory effects demonstrated by CLA supplementation make it a potential prospect for utilization in mitigating joint inflammation. …
The Avian Thrombocyte Is A Specialized Immune Cell, Farzana Ferdous
The Avian Thrombocyte Is A Specialized Immune Cell, Farzana Ferdous
All Dissertations
Thrombocytes are the most abundant circulating cells next to red blood cells in avian blood. Avian thrombocytes are homologous in function to mammalian platelets. Avian thrombocytes and the mammalian platelet are widely recognized contributors to inflammatory responses upon stimulation with various microbial stimulants. However, some observed responses of the avian thrombocyte depart from a standardized model ascribed to innate cells. To help unravel the role of thrombocytes in innate immunity, and possibly adaptive immunity, first we examined the surface features of chicken thrombocytes. Chicken thrombocytes constitutively express transcripts for different Toll-like receptors (TLRs) that are crucial for the innate immune …
Effects Of Creosote-Contaminated Sediment Extracts On Mouse Macrophage Physiology And Function, Rayna Silva
Effects Of Creosote-Contaminated Sediment Extracts On Mouse Macrophage Physiology And Function, Rayna Silva
All Theses
The southern branch of the Elizabeth River, at Portsmouth Virginia is one of the most polluted systems in North America. This harbor estuary system is also home to the Atlantic Wood Superfund site, which is heavily contaminated with creosote from the Atlantic Wood (AW) preservative company that ceased production in the later 1990s. Creosote is a mixture of polyaromatic hydrocarbons (PAHs), metals, and numerous aliphatic hydrocarbons, and well known to be carcinogenic. The toxicity of sediments and pore waters from the AW site has been studied extensively using Fundulus heteroclitus, also known as the mummichog, or Atlantic killifish. Most adult …
Anticancer Effects Of Red Raspberries On Immune Cells And Blood Parameters, Jannet Romero
Anticancer Effects Of Red Raspberries On Immune Cells And Blood Parameters, Jannet Romero
All Dissertations
There is an abundance of research correlating diets rich in fruits and vegetables to the reduction or prevention of chronic diseases such as cancer and cardiovascular disease. Plants extracts have also been claimed to possess antiviral, antibacterial, and immunological properties. This study focused on the in vitro and in vivo effects of a water extract from lyophilized Meeker red raspberries on tumor cell viability and immune parameters. A large number of studies have demonstrated the cytotoxic effect of different fruit juices and extracts against tumor cell lines in vitro. However, studies also show that the blood plasma levels of berry …
Immunomodulatory Properties Of Noni (Morinda Citrifolia), Madhukar Lohani
Immunomodulatory Properties Of Noni (Morinda Citrifolia), Madhukar Lohani
All Theses
Noni (Morinda citrifolia) is a popular medicinal plant of family Rubiaceae. Its fruit is rich in various phytochemicals and polysaccharides. Anecdotal evidence indicates that it was used to stimulate the immune system and, thus, to fight various infections. Limited in vitro studies also support the immunomodulatory role of Noni, however only one study utilized an animal model. The purpose of this study was to examine the immunomodulatory properties of Noni fruit the broiler chicken.
Different concentrations of dietary Noni were added to diets and fed to day-old broiler chickens for 3 to 6 weeks. Gut tissue and blood were sampled …