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Association Tests Of The Opioid Receptor System And Alcohol-Related Traits, Ryan Bennett
Association Tests Of The Opioid Receptor System And Alcohol-Related Traits, Ryan Bennett
Theses and Dissertations
The opioid receptors and their endogenous ligands have long been implicated in a variety of traits including addiction, impulsive behaviors and substance dependence. Using phenotypic measurements collected from the IASPSAD, data from a latent class analysis and data from a SNP array and additional genotyping assays, association and regression tests were performed to determine the effects of common SNPs encoded in the genes of the opioid receptors and ligands on various traits relating to alcohol dependence. Although only one SNP can be reported as significant for substance dependence within alcoholics, there were a few results approaching significance that may offer …