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Full-Text Articles in Medicine and Health Sciences
Computational Analysis Of Expression Of Human Embryonic Stem Cell-Associated Signatures In Tumors., Xiaosheng Wang
Computational Analysis Of Expression Of Human Embryonic Stem Cell-Associated Signatures In Tumors., Xiaosheng Wang
Journal Articles: Genetics, Cell Biology & Anatomy
BACKGROUND: The cancer stem cell model has been proposed based on the linkage between human embryonic stem cells and human cancer cells. However, the evidences supporting the cancer stem cell model remain to be collected. In this study, we extensively examined the expression of human embryonic stem cell-associated signatures including core genes, transcription factors, pathways and microRNAs in various cancers using the computational biology approach.
RESULTS: We used the class comparison analysis and survival analysis algorithms to identify differentially expressed genes and their associated transcription factors, pathways and microRNAs among normal vs. tumor or good prognosis vs. poor prognosis phenotypes …
Microarray-Based Cancer Prediction Using Single Genes., Xiaosheng Wang, Richard Simon
Microarray-Based Cancer Prediction Using Single Genes., Xiaosheng Wang, Richard Simon
Journal Articles: Genetics, Cell Biology & Anatomy
BACKGROUND: Although numerous methods of using microarray data analysis for cancer classification have been proposed, most utilize many genes to achieve accurate classification. This can hamper interpretability of the models and ease of translation to other assay platforms. We explored the use of single genes to construct classification models. We first identified the genes with the most powerful univariate class discrimination ability and then constructed simple classification rules for class prediction using the single genes.
RESULTS: We applied our model development algorithm to eleven cancer gene expression datasets and compared classification accuracy to that for standard methods including Diagonal Linear …