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Full-Text Articles in Medicine and Health Sciences
Structure And Function Of Asthma Evaluated Using Pulmonary Imaging, Rachel L. Eddy
Structure And Function Of Asthma Evaluated Using Pulmonary Imaging, Rachel L. Eddy
Electronic Thesis and Dissertation Repository
Asthma has been understood to affect the airways in a spatially heterogeneous manner for over six decades. Computational models of the asthmatic lung have suggested that airway abnormalities are diffusely and randomly distributed throughout the lung, however these mechanisms have been challenging to measure in vivo using current clinical tools. Pulmonary structure and function are still clinically characterized by the forced expiratory volume in one-second (FEV1) – a global measurement of airflow obstruction that is unable to capture the underlying regional heterogeneity that may be responsible for symptoms and disease worsening. In contrast, pulmonary magnetic resonance imaging (MRI) …
Fev1 And Mri Ventilation Defect Reversibility In Asthma And Copd, Hana Serajeddini, Rachel L Eddy, Christopher Licskai, David G Mccormack, Grace Parraga
Fev1 And Mri Ventilation Defect Reversibility In Asthma And Copd, Hana Serajeddini, Rachel L Eddy, Christopher Licskai, David G Mccormack, Grace Parraga
Medical Biophysics Publications
The underlying pathophysiological determinants of asthma and chronic obstructive pulmonary disease (COPD) are related in complex ways. Importantly however, post-bronchodilator FEV1- reversibility may occur in approximately 50% of COPD patients whilst epidemiological and magnetic-resonance-imaging (MRI) studies suggest that in asthmatics, FEV1-reversibility may diminish over time. As compared to patients with asthma or COPD alone, patients with coexisting asthma and COPD report worse clinical outcomes and increased healthcare costs and burden.